削痂对深Ⅱ度烧伤局部IL-8释放及创面炎性反应的影响

目的评价削痂手术对深Ⅱ度烧伤创面局部 IL-8水平和炎性反应程度的影响。方法检测7例烧伤病人深Ⅱ度创面削痂手术前、手术后和未手术之创面组织在体外组织培养中释放 IL-8的水平,同时通过组织病理学观察创面局部炎性反应程度。结果削痴手术后创面组织释放 IL-8水平较手术前和未手术创面有显著降低.局部组织形态学观察亦显示,手术后创面的炎性反应较手术前有明显减轻,未手术创面除有大量中性粒细咆浸润外,坏死范围较手术前扩大,残留的少量皮肤附件因炎症扩大而消失。结论削痂手术能减少局部组织 IL-8的释放,改善炎性反应,对防止深Ⅱ度创面组织进行性加深有积极意义。

The effect of tangential excision on the local IL-8 release and wound inflammatory response in deeppartial thickness burn

Objective The aim of this study is to investigate the effect of tangential excision on the local IL-8 release and wound inflammatory response.Methods The tissue specimens,which were taken from 7 patients with deep partial thickness burn before and after operation,were both cultured and histopathologically examined.The level of IL-8 in the culture medium was assayed ,meanwhile local inflammatory response of tissue samples was evaluated.Results The result showed that the level of IL- 8 is much lower in the postoperation wounds,while in the non-operation wounds the neutrophil infiltra- tion was marked,with enlargement in necrotic area and disappearance of skin appendages.Conclusion The findings suggested that tangential excision could reduce the local production of IL-8 and decrease lo- cal inflammatory response,which is helpful to prevent the progressive necrosis of burn wound.