咖啡摄入与尿石症发病风险的Meta分析

目的探讨饮用咖啡与尿石症发生风险的关系。方法计算机检索数据Pub Med、EMBASE、Web of science、Cochhrane Library、万方、维普,收集关于饮用咖啡与尿石症发生风险关系的观察性研究。两名研究员按纳入与排除标准独立筛选文献、提取资料后,应用STATA 11.0软件进行统计分析,并且分析了咖啡摄入与尿石症之间的剂量效应关系。结果共纳入文献6篇,其中队列研究2篇,病例对照研究4篇。Meta分析结果显示咖啡摄入可降低尿石症发生的风险(RR=0.70,95%CI=0.60～0.82)。剂量效应分析也显示了相同的结果。亚组分析结果显示,饮用咖啡的女性尿石症发生风险降低,不同地区的人群饮用咖啡对于降低尿石症风险的程度有差异。结论通过现有文献的Meta分析,饮用咖啡能降低尿石症发生的风险。

A Meta-Analysis of Coffee Intake and Risk of Urolithiasis

Objective Epidemiologic studies have reported various results relating coffee to urolithiasis. A meta-analysis of cohort and case-control studies was conducted to pool the relative risk (RR)estimates of the association between coffee and urolithiasis. Methods Eligible studies were retrieved via both computer searches and review of references. We analyzed abstracted data with random effects models to obtain the summary RR es-timates. A dose-response meta-analysis was performed for studies reporting categorical RR estimates for a se-ries of exposure levels. Results A total of 6 studies (2 cohort and 4 case-control studies)on coffee intake were included in the meta-analysis. The pooled odds ratio(OR)showed a significant influence of the highest coffee consumption (OR = 0. 70,95% confidence interval 0. 60~0. 82)on the risk of urolithiasis. Coffee exhibited an inverse dose-response relationship with urolithiasis. In stratified analysis,a significant inverse association between coffee and urolithiasis was observed in study design,geographical region and gender subgroup. Conclu-sions The overall current literature suggests that coffee intake is associated with a decreased risk of urolithiasis. Further efforts should be made to clarify the underlying biological mechanisms.