Olfactory Neuroblastoma |
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Authors: | Lester D R Thompson |
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Affiliation: | (1) Department of Pathology, Southern California Permanente Medical Group, Woodland Hills Medical Center, 5601 De Soto Avenue, Woodland Hills, CA 91365, USA |
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Abstract: | Few neoplasms are unique to the sinonasal tract, but sinonasal undifferentiated carcinoma and olfactory neuroblastoma are
malignant tumors which require unique management. Due to the rarity of these tumors, practicing pathologists are not always
aware of their distinctive clinical, radiographic, histologic, immunohistochemical, and molecular features. These cases are
frequently submitted for consultation, further suggesting the diagnostic difficulties inherent to these tumors. Specifically,
olfactory neuroblastoma is a neoplasm that can histologically mimic many tumors within the sinonasal tract, making recognition
of this tumor important, as the management frequently requires a bicranial-facial surgical approach, a trephination procedure
which can be quite technically difficult and challenging to achieve a good result. The management is therefore quite unique
in comparison to other sinonasal tract malignancies, setting it apart diagnostically and managerially from other lesions. |
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Keywords: | Olfactory neuroblastoma Esthesioneuroblatoma Sinonasal tract Cribriform plate Immunohistochemistry Synaptophysin Chromogranin CD56 S-100 protein Magnetic resonance Cranial nerve Lobular architecture Homer Wright pseudorosettes Flexner-Wintersteiner rosettes Neurofibrillary stroma Sinonasal undifferentiated carcinoma Mucosal melanoma Rhabdomyosarcoma Extranodal NK/T-cell lymphoma nasal type |
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