四环素局部应用对洁治和根面平整影响的Meta分析

目的：比较并评价在牙周炎治疗过程中,牙周袋内局部应用四环素辅助用于洁治和根面平整（Scaling and Root Planing,SRP）的临床效果是否优于单纯的SRP。方法：主要检索6个数据库,一些全文通过手工检索获得。收集至2009年5月公开发表的中英文牙周局部应用四环素辅助用于洁治和根面平整的随机对照试验,随访时间至少1个月。测量结果包括术后牙周探诊深度（probing depth,PD）的减少、临床附着水平（clinical attachment level,CAL）的增加。结果：最终8个研究纳入本系统评价。Meta分析结果显示牙周局部应用四环素辅助用于SRP与单纯SRP相比,可以使临床附着水平显著增加,而牙周探诊深度在两治疗组间无统计学差异。结论：在慢性牙周炎的治疗过程中,牙周局部应用四环素辅助用于SRP可以使附着水平显著增加。

Meta-Analysis on Effect of Local Tetracycline to Scaling and Root Planing

Objective：To assess the effectiveness of local delivery of tetracycline as an adjunct to scaling and root planing（SRP）versus SRP alone in patients with chronic periodontitis by Meta-analysis.Methods：The selected studies were pooled from six major electronic database to 2009for randomized controlled trials（RCTs）as tetracycline plus SRP versus SRP with at least 1month of follow-up.Several English journals were handsearched.Outcome measures were：probing depth（PD）reduction,clinical attachment level（CAL）gain.Results：Eight studies that met inclusion criteria were entered into the meta-analysis.A significant mean gain in CAL for the combined tetracycline and SRP was observed in two treatments,but there were no statistical significant differences in PD between the two treatments.Conclusion：Our results demonstrated the effectiveness of tetracycline as an adjunct to SRP on clinical attachment level gain in the treatment of chronic adult periodontitis.