| 壳聚糖-羧甲基壳聚糖膜的生物相容性研究 |
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| 引用本文： | 庄昭霞,林志勇,曹金芳.壳聚糖-羧甲基壳聚糖膜的生物相容性研究[J].上海口腔医学,2003,12(5):362-365. |
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| 作者姓名： | 庄昭霞 林志勇 曹金芳 |
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| 作者单位： | 1. 山东大学口腔医院牙周科,山东,济南,250012
2. 山东省立医院口腔内科,山东,济南,250021 |
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| 基金项目： | 山东省自然科学基金(Y98C09038) |
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| 摘 要： | 目的 观察壳聚糖-羧甲基壳聚糖作为牙周引导组织再生膜的生物相容性。方法 采用冷冻干燥法制备壳聚糖-羧甲基壳聚糖膜，然后通过细胞毒性试验、肌内植入试验等体内外生物学试验相结合的方法研究其生物相容性。结果 测试表明，壳聚糖-羧甲基壳聚糖膜无毒，膜植入早期出现巨噬细胞为主的炎症反应；随着膜的降解，炎症反应逐渐减轻，周围组织无不良反应。结论 壳聚糖-羧甲基壳聚糖膜具有良好的生物相容性。
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| 关 键 词： | 壳聚糖 羧甲基壳聚糖 生物相容性 引导组织再生 |
| 文章编号： | 1006-7248(2003)05-0362-04 |
| 修稿时间： | 2003年1月23日 |
Biocompatibility of Chitosan-Carboxymethylchitosan as Membrane for Periodontal Guided Tissue Regeneration |
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| ZHUANG Zhao-xia ,LIN Zhi-yong ,CAO Jin-fang ..Biocompatibility of Chitosan-Carboxymethylchitosan as Membrane for Periodontal Guided Tissue Regeneration[J].Shanghai Journal of Stomatology,2003,12(5):362-365. |
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| Authors: | ZHUANG Zhao-xia LIN Zhi-yong CAO Jin-fang |
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| Affiliation: | Department of Periodontology, School of Stomatology, Shandong University, Jinan 250012, China. |
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| Abstract: | Objective To investigate the biocompatibility of chitosan-carboxymethylchitosan as membrane for periodontal guided tissue regeneration(GTR).Methods Chitosan-carboxymethylchitosan blending membrane was prepared by freeze-drying and tests including cytotoxicity test,inserting the membrane into the rabbits ,muscles,were employed to investigate its biocompatibility.Results Chitosan-carboxymethylchitosan blending membrane showed no toxicity.In early period after the insertion of the membrane,inflammatory processes with macrophages were observed,but the processes reduced with the membrane degradation.Conclusion Chitosan-carboxymethylchitosan blending membrane has desirable biocompatibility. |
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| Keywords: | Chitosan Carboxymethylchitosan Biocompatibility GT |
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