| 牙龈卟啉单胞菌膜泡对牙龈上皮细胞MMPs基因表达的影响 |
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| 引用本文： | 寇育荣,潘亚萍.牙龈卟啉单胞菌膜泡对牙龈上皮细胞MMPs基因表达的影响[J].临床口腔医学杂志,2008,24(3):140-142. |
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| 作者姓名： | 寇育荣 潘亚萍 |
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| 作者单位： | 中国医科大学口腔医学院口腔内科,辽宁,沈阳,110001 |
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| 摘 要： | 目的:探讨牙龈卟啉单胞菌膜泡对牙龈上皮细胞基质金属蛋白酶(MMPs)基因表达的影响,揭示牙龈卟啉单胞菌在牙周炎中的致病作用.方法:以Real-time RT-PCR法检测牙龈卟啉单胞菌膜泡刺激下牙龈上皮细胞MMP-1和MMP-3的mRNA表达水平.结果:牙龈卟啉单胞菌膜泡显著地上调MMP-1和MMP-3 mRNA表达水平.结论:牙龈卟啉单胞菌诱导牙龈上皮细胞发生细胞炎症反应,可能是牙周炎发生、发展的重要因素.
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| 关 键 词： | 牙龈卟啉单胞菌 牙龈上皮细胞 基质金属蛋白酶 |
| 文章编号： | 1003-1634(2008)03-0140-03 |
| 修稿时间： | 2007年2月12日 |
Effects of Porphyromonas gingivalis vesicles on MMPs gene expression of gingival epithelial cells |
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| KOU Yu-rong,PAN Ya-ping.Effects of Porphyromonas gingivalis vesicles on MMPs gene expression of gingival epithelial cells[J].Journal of Clinical Stomatology,2008,24(3):140-142. |
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| Authors: | KOU Yu-rong PAN Ya-ping |
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| Abstract: | Objective:To study the effects of Porphyromonas gingivalis vesicles on matrix metalloproteinases(MMPs) gene expression of gingival epithelial cells and the pathogenesis of Porphyromonas gingivalis in periodontitis. Method:The effects of Porphyromonas gingivalis vesicles on MMP-1 and MMP-3 mRNA expression of gingival epithelial cells were determined by Real-time RT-PCR. Resulut:Porphyromonas gingivalis vesicles significantly up-regulated MMP-1 and MMP-3 mRNA expression of gingival epithelial cells. Conclusion:Cellular inflammatory responses of gingival epithelial cells induced by Porphyromonas gingivalis may contribute to the initiation and progression of periodontitis. |
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| Keywords: | Porphyromonas gingivalis gingival epithelial cell matrix metalloproteinases(MMPs) |
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