| 多孔β-磷酸三钙/胶原支架修复兔下颌牙槽骨缺损的实验研究 |
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| 引用本文： | 刘星纲,邓旭亮,邹超,吕培军,王新知.多孔β-磷酸三钙/胶原支架修复兔下颌牙槽骨缺损的实验研究[J].北京口腔医学,2014,22(1):1-4. |
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| 作者姓名： | 刘星纲 邓旭亮 邹超 吕培军 王新知 |
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| 作者单位： | 100081,北京大学口腔医学院修复科;北京大学口腔医学院特诊科;浙江大学材料化工学院材料系;首都医科大学口腔医学院修复科 |
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| 基金项目： | 国家高技术研究发展计划(863计划)(项目编号：2004AA302G50) |
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| 摘 要： | 目的观察自行研发的2种支架材料修复兔下颌牙槽骨临界骨缺损的效果。方法8只新西兰大白兔下颌骨制备10mm×8mm箱状骨缺损，分别植入多孔β-磷酸三钙／胶原与β-磷酸三钙／聚左旋乳酸2种支架材料，分别在4、6、8、12周时各处死2只。采用肉眼观察，锥形束CT与组织切片观察成骨效果与材料降解情况。结果β-磷酸三钙／胶原支架在各时间点成骨效果均好于对照组。在12周时，完全修复骨缺损。结论β-磷酸三钙／胶原支架可以快速、有效修复兔下颌牙槽骨临界骨缺损。
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| 关 键 词： | 牙槽骨缺损 骨组织工程学 β-磷酸三钙/胶原 β-磷酸三钙/聚乳酸 |
An experimental study of repairing mandibular alveolar bone defect of rabbit by β-tricalcium pbosphate/collagen |
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| LIU Xing-gang,DENG Xu-liang,ZOU Chao.An experimental study of repairing mandibular alveolar bone defect of rabbit by β-tricalcium pbosphate/collagen[J].Beijing Journal Of Stomatology,2014,22(1):1-4. |
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| Authors: | LIU Xing-gang DENG Xu-liang ZOU Chao |
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| Affiliation: | , LV Pei-jun, WANG Xin-zhi. Department of Prosthodontics, Peking University .School and Hospital of Stomatology,Beijing 100081, China |
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| Abstract: | Objective To examine the effect of repairing alveolar bone defect of rabbit by β-tricalcium phosphate/ collagen. Methods Eight rabbits were used in the study. The alveolar bone defect（ 10mm x 8mm） was prepared in two sides of mandible of each rabbit and repaired by β-tricalcium phosphate/collagen. The animals were sacrificed at 4,6,8 and 12 weeks after the repair. The specimens were examined by naked eye, CBCT and histology for bone formation and degradation. Results β-tricalcium phosphate/collagen was superior to the β-tricalcium phosphate/PLLA in the repair of bone defect at all time points. Conclusion β-tricalcium phosphate/collagen can rapidly repair the critical size of alveolar bone defect. |
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| Keywords: | Alveolar bone defect Bone tissue engineer 15-Tricalcium phosphate/collagen |
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