| 基因重组人骨形成蛋白-2和牛骨形成蛋白异位诱导成骨的比较 |
| |
| 引用本文： | 戴毅敏,陈新梅,毛天球,韩亮,马秦,陈富林.基因重组人骨形成蛋白-2和牛骨形成蛋白异位诱导成骨的比较[J].实用口腔医学杂志,2002,18(4):326-328. |
| |
| 作者姓名： | 戴毅敏 陈新梅 毛天球 韩亮 马秦 陈富林 |
| |
| 作者单位： | 1. 西安第四军医大学口腔医学院,710032
2. 成都四川大学口腔医学院 |
| |
| 摘 要： | 目的：观察基因重组人骨形成蛋白-2（rhBMP-2)和牛骨形成蛋白（bBMP)分别与珊瑚/聚乳酸形成复合人工骨的异位诱导成骨活性，同时比较两种骨形成蛋白的成骨效率，方法：把rhBMP-2和bBMP分别与珊瑚/聚乳酸形成复合人工骨，进行小鼠肌内种植1、3、6周后，组织学观察和组织形态测量，比较其异位诱导成骨活性。结果：rhBMP-2和bBMP存在骨诱导差异，rhBMP-2诱导成骨量相对较少但血管，骨髓含量丰富，bBMP则相反，结论：两种BMP都具有良好的诱骨活性，但在居骨量和血管，骨髓样组织的形成量上有明显不同。
|
| 关 键 词： | 基因重组 人骨形成蛋白－2 牛骨形成蛋白 异位诱导 成骨活性 实验研究 |
| 文章编号： | 1001-3733(2002)-04-0326-03 |
| 修稿时间： | 2001年1月3日 |
Bone formation induced by purified BMP and by recombinant human BMP-2 |
| |
| Dai Yimin,Chen Xinmei,Mao Tianqiu,et al..Bone formation induced by purified BMP and by recombinant human BMP-2[J].Journal of Practical Stomatology,2002,18(4):326-328. |
| |
| Authors: | Dai Yimin Chen Xinmei Mao Tianqiu |
| |
| Affiliation: | Dai Yimin,Chen Xinmei,Mao Tianqiu,et al.College of Stomatology,Fourth Military Medical University,Xi'an 710032 |
| |
| Abstract: | Objective: To study the biodegradable of coral PLA composite artifical bone combined with bBMP or rhBMP as a new kind of bone substitute material. Methods: The composites were implanted into the muscle pouches of mice after combined with rhBMP-2 or bBMP respectively. Ectopic osteoinductive activity of rhBMP-2 or bBMP was examined and compared by histology and histo-morphometry.Results: rhBMP-2 and bBMP had different osteoinductivety. rhBMP-2 appeared to induce less bone and more angioid tissue and marrow. While bBMP seemed to have opposite effects. Conclusion: bBMP is more osteoinductive than rhBMP-2. |
| |
| Keywords: | Bone morphogenetic protein Coral/PLA Composite artificial bone Osteoconductive |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
