| 珊瑚转化多孔羟基磷灰石复合rhBMP-2人工骨的动物实验研究 |
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| 引用本文： | 韩亮,毛天球,戴毅敏,马秦,李峰,赵宇.珊瑚转化多孔羟基磷灰石复合rhBMP-2人工骨的动物实验研究[J].实用口腔医学杂志,1999,15(4):286-288. |
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| 作者姓名： | 韩亮 毛天球 戴毅敏 马秦 李峰 赵宇 |
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| 作者单位： | 1. 北京海军总医院
2. 西安第四军医大学口腔医学院,710032 |
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| 摘 要： | 目的：寻找新的骨代用材料。方法：采用珊瑚转化多孔羟基磷石（ＣＨＡ）作为移植物支架，用Ｉ型胶原作为ｒｈＢＭＰ－２的缓释载体及赋形剂，将三者复合制成新型人工骨，进行了大鼠标准颅骨缺损骨移植实验。结果：ＣＨＡ／胶原具有良好的生物相容性和骨引导作用。ｒｈＢＭＰ－２／ＣＨＡ／胶原具有骨引导和骨诱导双重特性，其成骨效应明显优于单纯ＣＨＡ／胶原植入。结论：该复合人工骨有可能成为临床修复骨缺损的有效材料。
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| 关 键 词： | 珊瑚羟基磷灰石 羟基磷灰石类 骨移植材料 基因重组人骨形成蛋白－2 |
Effects of the composite of rhBMP-2 and coralline hydroxyapatite in bone defect repair |
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| Han Liang,Mao Tianqiu,Dai Yimin,et al..Effects of the composite of rhBMP-2 and coralline hydroxyapatite in bone defect repair[J].Journal of Practical Stomatology,1999,15(4):286-288. |
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| Authors: | Han Liang Mao Tianqiu Dai Yimin |
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| Affiliation: | Han Liang,Mao Tianqiu,Dai Yimin,et al.Stomatological College,Fourth Military Medical University,Xi'an 710032 |
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| Abstract: | Objective: To study the feasibility of rhBMP2hydroxyapatite composite for bone defect repair. Methods: A composite of coralline hydroxyapatite(CHA),used as bone graft supporting frame,human bone morphogenetic protein2(rhBMP2) and type I collagen,used as carrier of rhBMP2, was prepaired and transplanted into cranial defects of mice;the effects were observed. Result: CHA/collagen showed biocompatibility and osteoconductive activity;rhBMP2/CHA/collagen showed more osteoinductive and more osteoconductive than CHA/collagen. Conclusion: This combined artificial bone may be feasible for bone defect repair. |
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| Keywords: | Coralline hydroxyapatite(CHA) Hydroxyapatites Bone grafts Recombinant human bone morphogenetic protein2(rhBMP2) |
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