结直肠癌肿瘤组织中TMPRSS4、c-Met、KIF18A表达水平与其病理特性和生存状态的关系

目的探讨结直肠癌肿瘤组织中跨膜丝氨酸蛋白酶4(TMPRSS4)、间质表皮转化因子(c-Met)、驱动蛋白家族成员18A(KIF18A)表达水平与其病理特性和生存状态的关系。方法选取该院于2015年3月至2017年6月确诊的102例结直肠癌患者作为研究对象,比较癌变组织和癌旁组织TMPRSS4、c-Met阳性率及KIF18A水平的差异,不同病理状态及生存状态患者的TMPRSS4、c-Met阳性率及KIF18A水平的差异,分析患者的病理状态及生存状态与TMPRSS4、c-Met阳性率和KIF18A水平的相关性。结果癌变组织TMPRSS4、c-Met阳性率及KIF18A水平明显高于癌旁组织(P<0.05);不同性别、年龄患者TMPRSS4、c-Met阳性率及KIF18A水平比较差异均无统计学意义(P>0.05),而不同病程、TNM分期、临床分型患者之间比较差异有统计学意义(P<0.05);通过对患者的随访,生存患者61例,死亡患者41例,生存组TMPRSS4、c-Met阳性率及KIF18A水平明显低于死亡组(P<0.05);患者的TNM分期、临床分型、病程及生存状态与TMPRSS4、c-Met阳性率及KIF18A的水平呈正相关(r=0.165~0.998,P<0.05)。结论结直肠癌肿瘤组织中TMPRSS4、c-Met阳性率及KIF18A水平与其病理特性和生存状态存在一定的相关性,可作为结直肠癌患者诊断辅助参考之一。

Relationship between the expression level of TMPRSS4,c-Met and KIF18A in colorectal cancer and their pathological characteristics and survival status

Objective To investigate the relationship between the expression level of transmembrane serine protease 4(TMPRSS4),c-Mesenchymal-epithelial transition factor(c-Met)and Kinesin Family Member 18A(KIF18A)in colorectal cancer and their pathological characteristics and survival status.Methods A total of 102 patients with colorectal cancer diagnosed in the hospital from March 2015 to June 2017 were selected as the research objects.The difference of positive rates of TMPRSS4,c-Met and KIF18A level in cancer tissues and adjacent tissues,the differences of positive rates of TMPRSS4,c-Met and KIF18A level in patients with different pathological and survival states were compared.The relationship between pathological and survival states and positive rates of TMPRSS4,c-Met and KIF18A level was analyzed.Results The positive rates of TMPRSS4,c-Met and KIF18A level in cancer tissues were significantly higher than those in adjacent tissues(P<0.05).There were no significant differences in the positive rates of TMPRSS4,c-Met and KIF18A level in patients of different genders and ages(P>0.05),but there were significant differences in patients with different course,TNM stage and clinical classification(P<0.05).According to the follow-up of the patients,61 patients survived and 41 died,the positive rates of TMPRSS4,c-Met and KIF18A level in the survival group were significantly lower than those in the death group(P<0.05).The TNM stage,clinical classification,course of disease and survival status of the patients were positively correlated with positive rates of TMPRSS4,c-Met and KIF18A level(r=0.165-0.998,P<0.05).Conclusion The positive rates of TMPRSS4,c-Met and KIF18A level in colorectal cancer tissues are correlated with their pathological characteristics and survival status,which could be used as an important target for diagnosis and treatment of colorectal cancer in the future.