遗忘型轻度认知障碍的弥散张量成像研究

目的：应用3.0T磁共振弥散张量成像（Diffusion tensor imaging，DTI）分别评价遗忘型轻度认知障碍患者（Amnestic mild cognitive impairment，aMCI）和正常对照志愿者（Normal controls，NC）不同脑白质区的各向异性分数（Fractional anisotrophy，FA）的差异。方法：分别对通过特利尔认知评估量表（Montreal cognitive assessment，MoCA）、简易智能状态检测（Minimental state examination，MMSE）评分筛查的28例aMCI、28例NC行常规MRI扫描及DTI扫描，应用FiberTrak软件包处理后测定DTI图像上不同脑白质区的FA值，并分析两组间各相同部位FA值的差异。结果：aMCI组右侧额叶、双侧海马旁白质、胼胝体膝部及胼胝体压部FA值较NC组降低，差异具有统计学意义（P＜0.05）。结论：aMCI患者脑白质纤维微观结构发生变化，提示DTI检查对aMCI的早期诊断有帮助。

The application of diffusion tensor imaging on 3.0T MR in amnestic mild cognitive impairment

Objective: To evaluate the fractional anisotrophy(FA) value of white matter in patients with amnestic mild cognitive impairment(aMCI) and normal controls(NC) with diffusion tensor imaging(DTI) on 3.0T MR.Methods: Twenty-eight NC and 28 aMCI who were diagnosed with Montreal cognitive assessment(MoCA) and minimental state examination(MMSE) scores underwent conventional MRI and DTI.FA values were measured in different brain regions with FiberTrak Package and then were compared between the two groups.Results: FA value decreased in both sides of parahippocampal gyrus,genu and splenium of corpus callusum in patients with aMCI.Conclusions: Changes in the microstructure of the white matter integrity can be observed in patients with aMCI,indicating that the DTI examination is helpful for early diagnosis of aMCI.