外周血NLR、dNLRPLR和RDW在妊娠期糖尿病诊断中的应用价值

目的探讨外周血中性粒细胞/淋巴细胞比值(NLR)、间接中性粒细胞/淋巴细胞比值(dNLR)、血小板/淋巴细胞比值(PLR)和红细胞体积分布宽度(RDW)在妊娠期糖尿病(GDM)诊断中的应用价值。方法选择2019年1-2月妊娠24~28周在该院产科门诊行口服75 g葡萄糖耐量试验(75 g OGTT)诊断为GDM的孕妇42例作为GDM组,随机选择同期血糖正常且孕周、孕产次与GDM组匹配的孕妇42例作为对照组。检测2组孕妇的血糖、NLR、dNLR、PLR和RDW水平,并进行统计学分析。结果2组孕妇的年龄、空腹血糖(FPG)、75 g OGTT 1 h血糖(1 h-PG)、75 g OGTT 2 h血糖(2 h-PG)、NLR和dNLR水平比较差异有统计学意义(P<0.05)。GDM孕妇NLR、dNLR水平与FPG无相关性(P>0.05),而NLR、dNLR与1 h-PG、2 h-PG呈正相关(P<0.05)。NLR和dNLR诊断GDM的受试者工作特征曲线下面积分别为0.7217、0.7132,最佳临界值分别为3.690、2.695。结论NLR和dNLR水平与GDM存在相关性,提示NLR和dNLR水平对GDM有一定的诊断价值。

Application value of peripheral blood NLR,dNLR,PLR and RDW in the diagnosis of gestational diabetes mellitus

Objective To investigate the application value of the peripheral blood neutrophil/lymphocyte ratio(NLR),indirect neutrophil/lymphocyte ratio(dNLR),platelet/lymphocyte ratio(PLR)and red blood cell volume distribution width(RDW)in the diagnosis of gestational diabetes mellitus(GDM).Methods Forty-two pregnant women with GDM diagnosed by oral 75 g glucose tolerance test(75 g OGTT)in the obstetric clinic of the hospital from January to February in 2019 were selected as GDM group,and forty-two pregnant women with normal blood glucose and matched gestational weeks and times of pregnancy and delivery in the same period were randomly selected as control group.The levels of plasma glucose,NLR,dNLR,PLR and RDW were detected and analyzed statistically.Results The age,fasting plasma glucose(FPG),75 g OGTT 1 h plasma glucose(1 h-PG),75 g OGTT 2 h plasma glucose(2 h-PG),NLR and dNLR levels of pregnant women in the two groups were significantly different(P<0.05).The levels of NLR and dNLR in GDM group were not correlated with FPG level(P>0.05),but the levels of NLR and DNLR were positively correlated with 1 h-PG and 2 h-PG(P<0.05).The area under the receiver operating characteristic curve of NLR and dNLR were 0.7217 and 0.7132 respectively,and the optimal cut-off values were 3.690 and 2.695 respectively.Conclusion There is a correlation between NLR and dNLR levels and GDM,suggesting that NLR and dNLR levels have certain predictive and diagnostic value for GDM.