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GRADE在诊断准确性试验系统评价中应用的原理、方法、挑战及发展趋势
引用本文:陈耀龙,;姚亮,;杜亮,;曾宪涛,;韦当,;王琪,;王小琴,;杨克虎.GRADE在诊断准确性试验系统评价中应用的原理、方法、挑战及发展趋势[J].中国循证医学杂志,2014(11):1402-1406.
作者姓名:陈耀龙  ;姚亮  ;杜亮  ;曾宪涛  ;韦当  ;王琪  ;王小琴  ;杨克虎
作者单位:[1]甘肃省循证医学与临床转化重点实验室,兰州730000; [2]兰州大学循证医学中心兰州大学基础医学院,兰州730000; [3]中国GRADE中心兰州大学,兰州730000; [4]四川大学华西医院中国循证医学中心,成都610041; [5]武汉大学中南医院循证与转化医学中心,武汉430071
基金项目:甘肃省循证医学与临床转化重点实验室开放基金
摘    要:诊断性试验的系统评价按基于原始研究的类型可分为两类:一类是基于诊断性随机对照试验的系统评价,其GRADE分级与干预性系统评价的方法类似;另外一类是基于诊断准确性试验的系统评价,其GRADE分级原理和方法是本文论述的重点。本文主要从理论分析的角度阐述了GRADE在诊断准确性试验系统评价中应用的原理、方法以及挑战。

关 键 词:GRADE  证据分级  系统评价  诊断性试验

Rationales,Methods, Challenges and Development Tendency of Using GRADE in Systematic Reviews of Diagnostic Accuracy Tests
Affiliation:CHEN Yao-long, YAO Liang, DU Liang, ZENG Xian-tao, WEI Dang, WANG Qi,WANG Xiao-qin, YANG Ke-hu(1. Key Laboratory of Evidence-based Medicine and Knowledge Translation of Gansu Province, Lanzhou 730000, China; 2. Evidence-based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China; 3. Chinese GRADE Center, Lanzhou University, Lanzhou 730000, China; 4. Chinese Evidence-Based Medicine Center, West China Hospital, Sichuan University, Chengdu 610041, China; 5. Center for Evidence-based Medicine and Translational Research, Zhongnan Hospital, Wuhan University, Wuhan 430071, China)
Abstract:Depending on different designs of original studies, systematic reviews of diagnostic studies could be cat- egorized into two kinds: one is based on diagnostic randomized controlled trials, of which the GRADE rating approach is similar to that of interventional systematic reviews; and the other is based on diagnostic accuracy tests, of which the GRADE rating approach is introduced in this article. This article explains the application of GRADE in systematic reviews of diagnostic accuracy tests mainly from the angle of theoretical analysis, including rationales, methods, and challenges.
Keywords:GRADE  Grading evidence  Systematic review  Diagnostic test
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