乳腺癌组织中c-erbB-2与pS2的临床意义及其关系

目的 探讨乳腺癌组织中c-erbB-2与pS2的表达及其相关性,并探讨其与乳腺癌临床病理特征以及与雌激素受体(ER)的相关性.方法 收集清华大学第一附属医院普外科2004年1月至2010年12月手术治疗并经病理检查确诊的乳腺癌患者标本79例,临床病理资料齐全.用免疫组织化学法检测79例乳腺癌标本中c-erbB-2与ps2的表达情况,分析不同临床病理特征与其表达的关系.结果 乳腺癌中c-erbB-2和pS2的阳性表达率分别是54.4％和59.5％.c-erbB-2的表达与淋巴结转移(D＜0.01)、组织学分级(P＜0.05)、TNM分期(P＜0.05)关系均具有统计学意义；pS2的表达与绝经状况(P＜0.01)与年龄(P＜0.05)关系有统计学意义.ER(+)组c-erbB-2的阳性表达率低于ER( -)组(P＞0.05),ER(+)组pS2的阳性表达率高于ER(-)组(44.4％,8/18),pS2(+)组c-erbB-2的阳性表达率高于pS2(-)组(P＜0.05).结论 联合检测乳腺癌组织中c-erbB-2及pS2的表达对于判断乳腺癌预后和指导治疗具有重要的临床价值.

Clinical significance of the expression of c.erbB-2 and pS2 in breast cancer tissues and their correlation analysis

Objective To study clinical significance of the expression of c-erbB-2 and pS2 in breast cancer tissues and their correlation analysis. Methods Immunohistochemistry method was used to analyze the expression of c-erbB-2 and pS2 in 79 cases of breast cancers. Results Positive expression rates of e-erhB-2 and pS2 in 79 cases of breast cancers were 54.4% and 59.5%. The expression of c-erbB-2 was correlated with lymph node metastasis ,the histological grades,and the TNM stage. The expression of pS2 was correlated with age and menopause status. The positive expression rate of c-erbB-2 was significantly higher in pS2 positive groups than in pS2 negative groups. Conclusions Combined detection of expressions of c-erbB-2 and pS2 in breast carcinoma has practical value in the evaluation of prognosis and therapeutic effects of breast cancer patients.