2型糖尿病患者血糖、血脂与轻度认知功能损害的关系

【目的】探讨2型糖尿病（T2DM）患者轻度认知功能损害（MCI）的相关因素。【方法】采用蒙特利尔认知评估（MoCA）北京版量表作为认知功能的主要测评工具，选取T2DM合并MCI患者58例为研究对象，T2DM无MCI患者60例为对照。空腹静脉采血。测定入选病例的糖化血红蛋白（HbAlc）、血脂、肝肾功能。【结果】与对照组比较，MCI组非高密度脂蛋白胆固醇（NHDL—C）、胆固醇（TC）、甘油三酯（TG）、HbAIc水平明显升高（P〈0．01），高密度脂蛋白胆固醇（HDL-C）水平降低（P〈0．01），低密度脂蛋白胆固醇（LDL—C）、丙氨酸转氨酶（ALT）、肌酐（Cr）差异无统计学意义。两组糖尿病（DM）病程、体重指数（BMI）差异具有统计学意义（均P〈0．05）。【结论】NHDL—C是DM并发MCI危险性评估的一项有用的指标。T2DM患者血糖控制不良、血脂紊乱等因素与认知功能损害相关。

Correlation of Blood Glucose and Blood Lipid with Mild Cognitive Impairment in Type 2 Diabetic Patients

Objective] To analyze the related factors of mild cognitive impairment（MCI） in patients with type 2 diabetes mellitus （T2DM）. Methods] Montreal cognitive assessment （MoCA） （Beijing version） was chosen as cognition assessment implement. Fifty eight cases of T2DM complicated with MCI were enrolled as the research group and 60 cases of T2DM without MCI were enrolled as the control group. Fasting blood samples were collected. HbAlc, blood lipid, liver and renal function were measured in all subjects. Results]Compared with control group, non-high-density lipoprotein-cholesterol（NHDL-C）, total cholesterol（TC）, triglycerides（TG） and HbAlc increased, and high-density lipoprotein-cholesterol（HDL-C） decreased in MCI group, and there were significant differences between two groups（ P d0.01）. There was no significant difference in low-density lipoprotein-cholesterol（LDL-C）, alanine transaminase（ALT） and creatinine（CREA） between two groups. There were significant difference in the duration of diabetes mellitus and body mass index（BMI） between two groups（all P d0.05）. Conclusion] NHDL is the useful indicator for the risk assessment of MCI in T2DM. The factors such as dyslipidemia and inefficient control of blood glucose are associated with cognitive impairment in T2DM patients.