| 甲状腺单发结节超声造影与微血管密度的相关性 |
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| 引用本文： | 顾继英,白敏,张学梅,杜联芳,胡宏慧.甲状腺单发结节超声造影与微血管密度的相关性[J].中国医学影像技术,2011,27(10):2006-2009. |
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| 作者姓名： | 顾继英 白敏 张学梅 杜联芳 胡宏慧 |
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| 作者单位： | 1. 上海交通大学医学院附属第一人民医院超声科,上海,200080
2. 上海交通大学医学院附属第一人民医院病理科,上海,200080 |
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| 基金项目： | 上海市级医院适宜技术联合开发推广应用项目(SHDC12010221)、上海市科委科技攻关计划项目(10411951800)。 |
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| 摘 要： | 目的 探讨甲状腺单发结节CEUS的特点及其与微血管密度(MVD)间的相关性。方法 对45例甲状腺单发甲状腺结节患者术前行CEUS,分析结节的造影特点;术后以CD34单克隆抗体染色肿瘤组织,于光镜下计数肿瘤的微血管数。结果 结节性甲状腺肿23例,腺瘤8例,甲状腺癌14例,CEUS峰值强度分别为(26.82±4.48)dB,(31.50±4.22)dB,(22.36±6.13)dB,MVD分别为(58.55±7.32)条/高倍视野、(68.67±10.62)条/高倍视野、(35.00±6.16)条/高倍视野,峰值强度与MVD呈正相关(r=0.692,P=0.001)。结论 CEUS对甲状腺结节有一定诊断价值,其峰值强度可反映结节的MVD,可于术前反映结节的血管生成情况。
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| 关 键 词： | 甲状腺结节 超声检查 造影剂 峰值强度 微血管密度 |
| 收稿时间： | 2011/3/27 0:00:00 |
| 修稿时间： | 2011/6/30 0:00:00 |
Relationship between contrast enhanced ultrasound manifestations and microvessel density of solitary thyroid nodule |
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| GU Ji-ying,BAI Min,ZHANG Xue-mei,DU Lian-fang and HU Hong-hui.Relationship between contrast enhanced ultrasound manifestations and microvessel density of solitary thyroid nodule[J].Chinese Journal of Medical Imaging Technology,2011,27(10):2006-2009. |
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| Authors: | GU Ji-ying BAI Min ZHANG Xue-mei DU Lian-fang and HU Hong-hui |
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| Affiliation: | Department of Ultrasound, Shanghai First People's Hospital,Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China;Department of Ultrasound, Shanghai First People's Hospital,Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China;Department of Pathology, Shanghai First People's Hospital,Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China;Department of Ultrasound, Shanghai First People's Hospital,Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China;Department of Pathology, Shanghai First People's Hospital,Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China |
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| Abstract: | Objective To observe the relationship between CEUS manifestations and microvessel density (MVD) of solitary thyroid nodule. Methods Forty-five patients with solitary thyroid nodule underwent CEUS before operation, and the characteristics of CEUS nodules were analyzed. After surgery, the tumor tissue were stained with CD34 monoclonal antibody, and the number of micro-vessels in the tumor was counted under microscope. Results There were 23 nodular goiters, 8 adenomas and 14 thyroid carcinomas. Their peak intensity (PI) was (26.82±4.48)dB, (31.50±4.22)dB and (22.36±6.13)dB, respectively, and MVD was 58.55±7.32, 68.67±10.62 and 35.00±6.16 vessels per high power field, respectively. PI positively correlated with MVD (r=0.692, P=0.001). Conclusion CEUS has certain value in diagnosis of thyroid nodules. PI can reflect MVD of thyroid nodules, therefore can be used to evaluate the angiogenesis of thyroid nodules before operation. |
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| Keywords: | Thyroid nodule Ultrasonography Contrast media Peak intensity Microvascular density |
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