骨科植入物表面细菌生物膜的研究与机制

背景：细菌形成生物膜后耐药性极强,而外科感染特别是骨科植入物感染与植入材料表面形成细菌生物膜密切有关。目的：综述了细菌生物膜形成、结构、影响因素、耐药机制及防治措施的研究进展。方法：以＂Bacterial biofilm,Drug resistance,Implant,Infection＂为英文检索;以＂细菌生物膜,耐药性,植入物,感染＂中文检索词,检索CNKI和PubMed数据库1982年1月至2011年9月有关细菌生物膜及其防治,植入物术后感染形成生物膜相关研究。纳入34篇文献进行分析。结果与结论：抗生素应用不能有效清除细菌生物膜,还可诱导耐药性产生。改变生物膜的微环境、选择生物相容性好的内植入材料和降低细菌的黏附性可以更加有效控制感染。

Research and mechanism of bacterial biofilm on the surface of orthopedic implants

BACKGROUND：After the formation of biofilm,drug resistance of bacteria will become strong,but surgical infection,especially the orthopedic implant infection is related to bacterial biofilm on the surface of materials.OBJECTIVE：To review the mechanism and research progress of the formation,structure,influencing factors,drug-resistant mechanisms,prevention and control measures of bacterial biofilm.METHODS：The CNKI database and PubMed database from January 1982 to September 2011 were used to search the articles on prevention treatment of bacterial biofilm and the formation of biofilms after postoperative infection of implants.A total of 34 articles were included to review.RESULTS AND CONCLUSION：The using of antibiotics can effectively remove the bacterial biofilms,and lead to the drug resistance.Changes in the microenvironment of the biofilm,good biocompatibility of implant materials selection and lower bacterial adhesion may be the future direction of anti-infective research.