自体骨、同种异体骨及骨形态发生蛋白重组骨治疗腰椎骨折

背景：骨形态发生蛋白重组骨是一种新型植骨材料，已逐步应用于临床，但在椎骨折机骨融合中效果仍少见报道。 目的：比较自体骨、同种异体骨及骨形态发生蛋白重组骨治疗腰椎骨折的疗效差异。 方法：选择2005年3月至2009年3月南阳医学高等专科学校附属第一医院收治的腰椎骨折患者78例，根据植骨材料不同随机分为3组，分别植入自体骨、同种异体骨、骨形态发生蛋白重组骨。

Autogenous bone, allogeneic bone and bone morphogenic protein micromorselized bone for the treatment of lumbar fracture

BACKGROUND： Bone morphogenic protein micromorselized bone is a new type of bone graft materials which has been gradually applied in clinic, but the reports about the effect of bone graft fusion on the lumbar fracture are rare. OBJECTIVE： To compare the clinical effect of autogenous bone, allogeneic bone and bone morphogenic protein micromorselized bone for the treatment of lumbar fracture. METHODS： This study retrospectively collected 78 patients with lumbar spinal fracture in First Affiliated Hospital of Nanyang Medical College from March 2005 to March 2009, and the 78 patients were randomly divided into three groups, and the autogenous bone, allogeneic bone and bone morphogenic protein micromorselized bone were implanted respectively. RESULTS AND CONCLUSION： All the 78 patients were followed-up for 24 months. There was a significant difference of Japanese Orthopaedic Association score at 24 months after grafting, the Japanese Orthopaedic Association score in bone morphogenic protein group was 90% 〉 autogenous bone group 85% 〉 allogeneic bone group 70% （P 〈 0.05）; at 12 and 24 months after grafting, the Cobb angle in the allogeneic bone group was larger than that in the other two groups at 12 and 24 months after grafting, and also larger than that in the allogeneic bone group at 6 months after grafting （P 〈 0.05）, but smaller than that before grafting （P 〈 0.05）, and there was significant difference between autogenous bone group and bone morphogenic protein group （P 〉 0.05）; the bone fusion rate at different time points in the autogenous bone group was lower than that in the other two groups （P 〈 0.05）. Bone morphogenic protein micromorselized bone is equivalent to autogenous bone graft in treating lumbar fracture, both are superior to allogeneic bone transplantation, and bone morphogenic protein micromorselized bone can facilitate the bone fusion with good effect and to be recommended in the clinical application.