Influence of study goals on study design and execution |
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| Affiliation: | 1. Department of Physical Medicine and Rehabilitation, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO;2. Sports Medicine Research Institute, University of Kentucky, Lexington, KY;3. Geriatric Research Education and Clinical Center, VA Eastern Colorado Healthcare System, Denver, CO;1. Program in Biomechanics and Movement Science, University of Delaware, Newark, DE, United States;2. Department of Physical Therapy, University of Delaware, Newark, DE, United States;3. Department of Physical Therapy, Arcadia University, Glenside, PA, United States;4. Research Department, Shriners Hospital for Children, Philadelphia, PA, United States;1. Cochrane Oral Health, University of Manchester, Manchester, U.K.;2. Department of Orthodontics and Dentofacial Orthopedics, University of Bern, Bern, Switzerland;1. UPFR des sports, laboratoire C.3.S (E.A. 4660), département santé-activités physiques et sportives, université de Franche-Comté, 31, chemin de l’Épitaphe, 25000 Besançon, France;2. Pôle sport, direction régionale de la jeunesse, des sports et de la cohésion sociale, département sport de haut-niveau, 66, rue Saint-Sébastien, 13281 Marseille cedex 06, France |
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| Abstract: | From the viewpoint of a clinician who makes recommendations to patients about choosing from the multiple possible management schemes, quantitative information derived from statistical analyses of observational studies is useful. Although random assignment of therapy is optimal, appropriately performed studies in which therapy has been nonrandomly “assigned” are considered acceptable, albeit occasionally with limitations in inferences. The analyses are considered most useful when they generate multivariable equations suitable for predicting time-related outcomes in individual patients. Graphic presentations improve communication with patients and facilitate truly informed consent. |
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