Boron–18F containing positron emission tomography radiotracers: advances and opportunities |
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Authors: | Benjamin P Burke Gonçalo S Clemente Stephen J Archibald |
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Affiliation: | 1. Department of Chemistry, University of Hull, Hull, UK;2. Positron Emission Tomography Research Centre, University of Hull, Hull, UK |
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Abstract: | Standard 18F]fluorination methods to form carbon–fluorine bonds can have some limitations such as low yield and the requirement for harsh reaction conditions. Inorganic approaches include the formation of boron–18F]fluorine bonds and have the potential to give high specific activities at room temperature forming a bond that is stable in vivo. There is considerable potential in future applications, particularly in relation to multimodal imaging and the provision of rapid efficient labelling protocols. Copyright © 2014 John Wiley & Sons, Ltd. |
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Keywords: | boron fluorine‐18 radiolabelling fluoroborates BODIPY PET |
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