不同地区A组乙型溶血性链球菌T分型与耐药关系

目的　探讨我国 4个省市自然人群中学龄儿童A组乙型溶血性链球菌 (groupAofStreptococcus,GAS)T分型与耐药关系。方法　T凝集法将GAS进行T分型 ,再用Vitek微生物鉴定系统进行药敏试验。测试江陵 5 7株、丰满 95株、重庆 71株、广州 397株GAS。结果　不同T型的GAS对红霉素、氯林可霉素、四环素的耐药性有显著差异 (P <0 .0 5 ) ,对红霉素耐药率高的菌型依序为T4、T1、T11、T6、T12 ;对氯林可霉素耐药率高的菌型为T1、T12、T6 ;对四环素耐药率高的菌型为T11、T3/B、T12、T4、T1。除广州农村外 ,各地的优势菌型为T1型 ,但不同地区T1型GAS的耐药率有差异 (P <0 .0 1)。结论　 4个省市自然人群儿童中携带的GAS对红霉素、氯林可霉素、四环素耐药率与T型有关 ,不同T型的GAS耐药率不同 ;同一T型GAS的耐药性有地区差异

Study on the relationship between T type and antimicrobial resistance in Group A Streptococcus

Objective To research the relationship between T type and the antimicrobial resistance of Group A Steptococcus (GAS) in school children of 4 provices.Methods Six hundred and twenty of GAS isolates were collected from September 1988 to July 1994 in Chongqing,Hubei,Jilin and Guangdong province of China.T type of the 620 isolates was tested by T agglutination.Antimicrobial susceptibility testing to 10 antibiotics were verified with Vitek system.Results Obviously statistical differences for resistance rates to erythromysin,clindamycin and tetracycline were found in different T types of GAS (P<0.001).The types most resistant to erythromycin were T-type 4,1, 11,6 and 12 which were in turn reduced resistance.The types resistant to clindamycin were T1,12,6,in turn.The types resistant to tetracycline were T11,T3/B,12,4 and 1,in turn.The dominant resistant type in all the 4 provinces except for Guanzhou urban was T1, but the resistance rates of GAS in the four regions were different(P<0.01).Conclusions Antibiotic resistance rates of GAS in natural people of the four provinces of China are associated with T type. The resistance rates in different T type of GAS are different,and resistance rates of identical T type in various regions were different.