不同性别慢性精神分裂症患者认知功能障碍的差异

目的:探讨不同性别慢性精神分裂症患者认知功能障碍的差异及其影响因素。方法:我院收治的慢性精神分裂症住院患者135例纳入研究,根据性别分为男性组71例,女性组64例。采用阳性和阴性症状量表(PANSS)评定患者的临床症状,蒙特利尔认知评估量表(MoCA)评估患者的认知功能,对结果进行统计学分析。结果:男性组PANSS的阴性症状分高于女性组,男性组在MoCA总分、视空间与执行功能、记忆力项目上评分低于女性组,差异均有统计学意义(P0.05);经协方差分析后,男性记忆力评分仍低于女性患者(P0.01)。结论:慢性精神分裂症男性患者认知功能障碍较女性严重,记忆障碍尤为明显。

Differences in Cognitive Dysfunction of Schizophrenic Patients with Different Genders

To explore the differences in cognitive dysfunction of schizophrenic patients with different genders and analyze the influencing factors. Methods: 135 patients with chronic schizophrenia treated in our hospital were enrolled in this study and were divided into the male group (n=71) and female group (n=64). Clinical symptoms were assessed by the positive and negative symptom scale (PANSS), and cognitive functions were assessed by the Montreal cognitive assessment (MoCA). The results were statistically analyzed. Results: The negative symptom score in PANSS of male patients was higher than that of female patients, but male patients had significantly lower scores in total score, visual space and executive function score, and memory score in MoCA than those of female patients (P<0.05). After covariance analysis, the memory score of male patients was still lower than that of female patients (P<0.01). Conclusion: Male patients with chronic schizophrenia suffer more serious cognitive dysfunction than female patients, especially in memory impairment.