适度间歇性低氧对临床相关疾病的康复作用

目的 系统综述适度间歇性低氧(IH)对临床相关疾病的康复作用。方法 通过关键词检索和滚雪球方式在PubMed、ScienceDirect数据库、中国知网、万方检索适度IH对临床相关疾病康复作用的相关文献,检索时间2004年至2021年。结果 共获得有效文献27篇,主要集中在适度IH对神经系统、呼吸系统和心血管疾病的作用,对机体代谢的调节和改善运动能力方面的研究。结论 适度IH能改善认知功能,缓解脑缺血性卒中症状,加速脊髓损伤恢复,抗抑郁,降血压,调节机体代谢,改善有氧运动能力,增强呼吸功能,并对冠心病具有康复作用。但应用于临床还需深入研究,特别是IH干预的低氧浓度、每次IH的周期及频率、干预切入时机及整个疗程的时间均需要进一步确定和规范。

Rehabilitation of Moderate Intermittent Hypoxia on Clinical Related Diseases (review)

Objective To systematically review the rehabilitation effects of moderate intermittent hypoxia on clinical related diseases.Methods Literatures about rehabilitation effects of moderate intermittent hypoxia on clinical related diseases from 2004 to 2021 were searched in PubMed, ScienceDirect, CNKI and Wanfang databases using a systematic review method.Results A total of 27 literatures were included, which focused on the effects on neural system, respiratory system, and cardiovascular diseases, as well as the regulation of metabolic and the improvement of exercise ability.Conclusion Moderate intermittent hypoxia could improve the cognitive function, alleviate the symptoms of ischemic stroke, accelerate the recovery of spinal cord injury, resist depression and reduce blood pressure; regulate metabolism, improve aerobic capacity, enhance respiratory function and myocardial function. However, more researches are needed to make it clear that the standard on the duration of hypoxia within episodes, the number of hypoxia/reoxygenation cycles (episodes) per session every day, the pattern of presentation, and the cumulative duration of exposure.