喹硫平与舒必利对精神分裂症患者血清泌乳素水平的影响

目的评价喹硫平与舒必利对精神分裂症患者血清泌乳素水平的影响。方法将90例精神分裂症患者随机分为喹硫平组和舒必利组，每组45例，分别口服喹硫平与舒必利治疗，观察4周。抽取同期30名健康体检者设为对照组。于治疗前及治疗第1周、2周、3周、4周末采用阳性与阴性症状量表评定临床疗效，同时采用放射免疫法检测血清泌乳素水平；对照组于人组时检测血清泌乳素。结果治疗后两组阳性与阴性症状量表总分均较治疗前有显著下降（P〈0．05或0．01）；喹硫平组治疗第1周、2周、3周末PANSS总分均较舒必利组下降显著（P〈0．05或0．01）。舒必利组男女患者治疗后血清泌乳素水平均呈持续性升高，治疗第3周、4周末均显著高于奎硫平组和对照组（P〈0．05或0．01）；喹硫平组男女患者治疗前后血清泌乳素水平均无显著变化，且与对照组无显著性差异（P〉0．05）。结论喹硫平治疗精神分裂症疗效显著，较舒必利起效更快，且对血清泌乳素水平无明显影响；而舒必利治疗可引起血清泌乳素水平升高。

Effects of quetiapine and sulpiride on the serum prolactin levels of schizophrenics

Objective To evaluate the effects of quetiapine and sulpiride on the serum prolactin levels of schizophrenics. Methods Ninety schizophrenics were randomly divided into quetiapine and sulpiride group（both n= 45） taking orally quetiapine and sulpiride respectively for 4 weeks. Thirty healthy cases were assigned to control group. Effieacies were assessed with the Positive and Negative Syndrome Scale（PANSS） before treatment and at the end of the 1^st ,2^nd ,3^rd and 4^th week and serum prolactin levels detected using radio-immunity method at the same time; serum prolactin levels were detected at entry for the control group. Results After treatment, the PANSS total scores of both research groups lowered more significantly compared with pretreatment （P〈0.05 or 0.01） ; the PANSS total scores at the end of the 1st , 2nd and 3rd week lowered more significantly in quetiapine than in sulpiride group（P〈0.05 or 0.01）. After treatment, serum prolactin levels of male-female patients in sulpiride group heightened continuously and were significantly higher than those of the the quetiapine group at the end of the 3rd and 4th week（P〈0.05 or 0.01） ; pre-and post-treatment serum prolactin levels of male-female patients in quetiapine group had no significant changes and no differences from control group（P〉0.05）. Conclussion Quetiapine has an evident effect, takes effects more rapidly than sulpiride does and has no obvious influence on serum prolactin levels in schizophrenia; but sulpiride may cause ser- um prolactin levels to heighten.