磁共振新技术DKI和IVIM在中枢神经系统的研究现状

磁共振成像(MRI)技术在评估脑的解剖结构及功能变化方面得到日益广泛的应用。扩散峰度成像(DKI)是用于量化组织内水分子非高斯运动的磁共振新技术,是扩散成像技术的延伸,对于描绘脑组织微观结构具有独特优势。体素内不相干运动成像(IVIM)是近几年发展起来的无创评价活体组织内分子扩散运动及灌注的MRI新技术。本文对DKI和IVIM的成像原理以及对中枢神经系统的应用价值的研究进展予以综述。

Present research situation of diffusion kurtosis imaging and intravoxel incoherent motion of the brain

AbstractMagnetic resonance imaging (MRI) is widely applied in assessing the changes of function and anatomical structure of the brain. Diffusion kurtosis imaging (DKI) is a new and promising diffusion imaging technique, which expands from diffusion tensor imaging (DTI) towards quantiifcation of non-Gaussian water diffusion. DKI has been demonstrated to be highly sensitve and directionally speciifc in probing the microstructure of biological tissues. Intravoxel incoherent motion (IVIM) is a new non-invasive MRI perfusion technique, which defines the ability to separate blood perfusion from true diffusion effects via a proper choice of the number and distribution of diffusion weightings, or b-values. This article will review and discuss the basic principles and the latest progresses of DKI and IVIM in brain imaging.