脑脊液细胞学在神经梅毒中的诊断价值

目的　观察神经梅毒患者的脑脊液细胞学变化特点 ,探讨其诊断价值。方法　对 32例脑脊液标本进行离心染色 ,同时进行细胞计数、生化、梅毒血清非特异性试验 (RPR)、梅毒血清特异性试验 (TPHA)检查。结果　发现10例神经梅毒患者的脑脊液细胞学异常率 10 0 % ;2 2例无神经系统损害的梅毒患者异常率 4 5 .5 % (10 / 2 2 ) ,明显高于脑脊液细胞计数、RPR检查 (P <0 .0 5 ) ,而与TPHA、生化检查结果大致相当 (P >0 .0 5 )。结论　梅毒患者未出现神经系统损害以前在中枢神经系统已有免疫反应发生 ,脑脊液细胞学对神经梅毒早期诊断、早期预防方面具有一定价值。

Diagnosis value of cerebrospinal fluid cytology in neurosyphilis

Objective To observe the feature of cerebrospinal f luid(CSF) cytology variety and to approach its diagnosis value in neurosyphilis. Method Thirty-two samples were examined after centrifugal dyeing,and each had examinations including cell-counting, biochemistry, rapid plasma reagin test(RPR) and trepenema pallidum hemagglutination assay(TPHA). Results The rate of abnormity in CSF fluid cytology was 100% in neurosyphilis (10 cases).At the same time that was 45.5% in syphilis but without representation of neural damage(22 cases),the rate of abnormity in CSF fluid cytology just as TPHA and biochemistry(P> 0.05),was obviously higher than cell-counting, and RPR(P< 0.05). Conclusion The immunoreaction in nerve center system has happened before the representation of neural damage in neurosyphilis.CSF fluid cytology is helpful for diagnosing neurosyphilis early.