血清胱抑素C与2型糖尿病并发症的相关性研究

目的：研究血清胱抑素C （cystatin C,CysC）与2型糖尿病（T2DM）并发症的相关性.方法：将536例住院T2DM患者根据是否合并糖尿病慢性并发症分为不合并糖尿病并发症的对照组、合并周围血管病变（peripheral arterial disease,PAD）组、合并肾脏病变（diabetic nephropathy,DN）组、合并视网膜病变（diabetic retinopathy,DR）组、合并周围神经病变（diabetic peripheral neuropathy,DPN）组,记录患者的年龄、病程、身高、体质量、腰围、臀围,并检测空腹血糖（FPG）、糖化血红蛋白（HbA1c）、总胆固醇（TC）、三酰甘油（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、血清肌酐（Scr）、血清CysC、空腹胰岛素（FINS）、肾小球滤过率（GFR）等,计算体质量指数（BMI）、胰岛素抵抗指数（HOMA-IR）,比较各组间所测指标的差异性,并分析CysC与T2DM并发症的相关性.结果：PAD组、DN组、DR组及DPN组的血清CysC水平均高于对照组（P＜0.05）.结论：T2DM患者的血清CysC升高与合并糖尿病周围血管病变、肾脏病变、视网膜病变、周围神经病变等慢性并发症具有相关性.

Relationship of Serum Cystatin C with Diabetic Complications in Patients with Type 2 Diabetes Mellitus

Objective：To investigate the relationship of serum cystatin C （CysC） with diabetic complications in patients with type 2 diabetes mellitus（T2DM）.Methods：According to whether they were with chronic complications of diabetes,536 hospitalized T2DM patients were divided into control group （without complications）,peripheral arterial disease（PAD）group,diabetic nephropathy（DN）group,diabetic retinopathy（DR）group and diabetic peripheral neuropathy（DPN）group.The age,course,height,body weight,waist circumference and hip circumference of patients were recorded.Fasting plasma glucose （FPG）,blood glycated hemoglobin （HbA1c）,total cholesterol （TC）,triglyceride （TG）,high-density lipoprotein （HDL-C）,low density lipoprotein （LDL-C）,serum creatinine （Scr）,serum CysC,fasting serum insulin （FINS） and glomerular filtration rate （GFR） were detected.Body mass index （BMI） and insulin resistance index （HOMA IR） were calculated.All of the above parameters were compared among the five groups.The correlations of CysC with diabetic complications were analyzed.Results：Serum levels of CysC in PAD group,DN group,DR group and DPN group were significantly higher than that in the control group（P＜0.05）.Conclusions：High level of serum CysC may be correlated with the development of chronic complications of T2DM,including PAD,DN,DR and DPN.