| XPGC46T单核苷酸多态性与晚期结直肠癌对奥沙利铂化疗敏感性的关系 |
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| 引用本文： | 邓芳,梁军,殷蓓蓓,谷健.XPGC46T单核苷酸多态性与晚期结直肠癌对奥沙利铂化疗敏感性的关系[J].康复与疗养杂志,2009(3):205-207. |
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| 作者姓名： | 邓芳 梁军 殷蓓蓓 谷健 |
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| 作者单位： | 青岛大学医学院附属医院肿瘤治疗研究中心,山东青岛266003 |
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| 摘 要： | 目的探讨人着色性干皮病G组（XPG）C46T基因多态性与以奥沙利铂为主的晚期结直肠癌化疗敏感性的关系。方法经病理检查确诊的Ⅳ期结直肠癌病人73例,治疗前提取外周血DNA,应用TaqMan-MGB探针等位基因分型技术进行基因分型,比较其基因型与接受奥沙利铂化疗病人的2周期临床疗效、无进展生存期（PFS）的关系。结果C/C野生基因型病人的近期有效率（73.0%）明显高于C/T＋T/T突变基因型的病人（P=0.014）;C/C基因型病人PFS（中位时间为11个月）明显长于C/T＋T/T基因型病人（6个月）,差异具有显著性（χ^2=28.90,P〈0.01）。结论XPGC46T基因多态性可能与以奥沙利铂化疗的晚期结直肠癌病人化疗敏感性和生存时间相关。
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| 关 键 词： | 结直肠肿瘤 DNA修复基因 XPG 单核苷酸多态性 奥沙利铂 |
THE RELATIONSHIP BETWEEN GENETIC POLYMORPHISM OF XPGC46T AND RESPONSE TO OXALIPLATIN CHEMOTHERAPY FOR ADVANCED COLORECTAL CANCER |
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| Affiliation: | DENG FANG, LIANG JUN, YIN BEI-BEI, et al (Treatment and Research Center of Oncology, The Affiliated Hospital of Qingdao University Medical College, Qingdao 266003, China) |
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| Abstract: | Objective To investigate the association between genetic polymorphisms of XPGC46T and response to oxaliplatin-based chemotherapy of advanced colorectal cancer. Methods Blood samples of 73 patients with stage-Ⅳcolorectal cancer were obtained for DNA isolation before chemotherapy. XPG genotypes were detected by TaqMan-MGB probe methods. The association between genotypes and the clinical efficacy after two-cycle oxaliplatin chemotherapy and progression-free survival （PFS） in the patients were compared. Results The short-term effective power in patients with C/C genotype was 73.0%, showing much higher than those with C/T＋T/T of 44.4% （P=0. 014）. The median PFS in patients with C/C genotype was 11 months, much longer than those with C/T＋T/T of six months （χ^2 = 28.90, P〈0.01）. Conclusion The XPGC46T genetic polymorphisms may be associated with clinical responses to oxaliplatin-based chemotherapy and live time in advanced coloreetal cancer. |
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| Keywords: | Colorectal carcinoma DNA repair gene XPG Polymorphism single nucleotide Oxaliplatin |
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