单纯栓塞与支架辅助栓塞治疗颅内动脉瘤的临床效果及安全性分析

目的分析单纯栓塞与支架辅助栓塞治疗颅内动脉瘤的临床效果及安全性。方法选取2016年10月-2018年1月我院收治的86例颅内动脉瘤患者,依据治疗方法的不同均分为观察组(支架辅助栓塞治疗)和对照组(单纯栓塞治疗)。比较两组栓塞效果,术前及术后3、5、7个月改良Rankin量表(modified rankin scale,MRS)评分,治疗后6个月及1年复发率,以及并发症发生情况。结果观察组完全栓塞率为93.02%明显高于对照组完全栓塞率76.74%(P<0.05)。治疗后两组MRS评分随着时间的延长逐渐降低,且相同时间MRS评分观察组明显低于对照组,差异均有统计学意义(P<0.01)。治疗后1年观察组复发率为6.98%明显低于对照组复发率23.26%(P<0.05)。观察组并发症总发生率为34.88%明显高于对照组并发症总发生率11.63%(P<0.05),但两组急性血栓、血管痉挛、缺血性脑卒中、动脉瘤破裂发生率比较差异无统计学意义(P>0.05)。结论与单纯栓塞相比,支架辅助栓塞可提高颅内动脉瘤患者栓塞效果、改善预后并降低复发率,且不会增加出血性及缺血性并发症发生。

Clinical Effects and Safety of Simple Embolization and Stent-assisted Embolization in the Treatment of Intracranial Aneurysms

Objective To analyze the clinical effects and safety of simple embolization and stent-assisted embolization in the treatment of intracranial aneurysms(ICA).Methods Eighty-six patients with ICA who were admitted to our hospital from October 2016 to January 2018 were enrolled and evenly divided into the observation group(stent-assisted embolization)and the control group(simple embolization)according to different treatment methods.The embolization effects,scores of modified Rankin Scale(MRS)before operation and at 3,5 and 7 months after operation,recurrence rates at 6 months and 1 year after surgery,and the incidence of complications were compared between the two groups.Results The complete embolization rate of the observation group(93.02%)was significantly higher than that of the control group(76.74%)(P<0.05).After treatment,MRS scores of the two groups were gradually decreased with time,and the MRS score of the observation group was significantly lower than that of the control group at the same time point(P<0.01).The recurrence rate in the observation group at 1 year after treatment was 6.98%,which was significantly lower than that in the control group(23.26%)(P<0.05).The overall incidence of complications in the observation group was significantly higher than that in the control group(34.88%vs 11.63%)(P<0.05).There was no significant difference in incidence of acute thrombosis,vasospasm,ischemic stroke or aneurysm rupture between the two groups(P>0.05).Conclusion Compared with simple embolization,stent-assisted embolization can improve the effects of embolization in patients with ICA,improve prognosis and reduce recurrence rate,without increasing the incidence of hemorrhagic and ischemic complications.