| 急性髓系白血病中uPA和uPAR的表达及意义 |
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| 引用本文： | 刘宝芹,邵雪斋,方艳秋.急性髓系白血病中uPA和uPAR的表达及意义[J].中国实验诊断学,2011,15(5):891-892. |
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| 作者姓名： | 刘宝芹 邵雪斋 方艳秋 |
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| 作者单位： | 1. 承德医学院附属医院,血液科,河北,承德067000
2. 吉林省人民医院,医学实验诊治中心,吉林,长春130021 |
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| 基金项目： | 吉林省自然科学基金项目 |
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| 摘 要： | 目的观察急性髓系白血病人骨髓单个核细胞uPAR（CD87）的表达及血浆uPA的水平,并探讨其临床意义。方法用ELISA法测定22例急性髓系白血病患者（观察组）及34例良性血液病患者（对照组）血浆中uPA表达水平,用流式细胞学技术测定骨髓单个核细胞uPAR水平,比较两组之间的表达差异。结果血浆中uPA水平和骨髓单个核细胞uPAR水平急性髓系白血病组均高于良性血液病组,差异具有显著性（P〈0.05）;pearson相关分析显示uPA表达水平及uPAR水平之间存在正相关性（观察组r1=0.614,对照组r2=0.921;P〈0.05）。结论急性髓系白血病患者血浆uPA水平及骨髓单个核细胞uPAR表达均升高,二者具有协同表达关系,联合检测对于急性髓系白血病的病情监控和预后分析有临床指导意义。
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| 关 键 词： | 急性髓系白血病 uPA uPAR |
uPA and uPAR expression in acute myeloid leukemia and the clinical implication |
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| LIU Bao-qin,SHAO Xue-zhai,FANG Yan-qiu.uPA and uPAR expression in acute myeloid leukemia and the clinical implication[J].Chinese Journal of Laboratory Diagnosis,2011,15(5):891-892. |
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| Authors: | LIU Bao-qin SHAO Xue-zhai FANG Yan-qiu |
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| Affiliation: | LIU Bao-qin1,SHAO Xue-zhai1,FANG Yan-qiu2.(1.The Affiliated Hospital of Chengde Medical College,Chengde,Hebei 067000,China,2.Jilin Province Hospital,Changchun 130021,China) |
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| Abstract: | Objective To investigate the uPAR expression in bone marrow mononuclear cell(MNC) and uPA plasma level in acute myeloid leukemia(AML) and furthermore to explore the clinical importance.Methods 22 cases of diagnosed acute myeloid leukemia(AML groups) and 34 cases of benign blood diseases(control groups) were enrolled in this study.The expression of uPAR of bone marrow MNC was detected by flow cytometry and uPA plasma level was detected by ELISA in two groups.Results The uPAR expression in BM MNC and plasma l... |
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| Keywords: | uPA uPAR |
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