N-乙酰-5-甲氧色胺镇痛作用的实验研究

目的为了寻找新型镇痛药物,对N-乙酰-5-甲氧色胺(Mel)的镇痛作用及其与哌替啶(Pt)的协同作用进行探索性研究。方法采用小鼠热板法及冰乙酸致小鼠扭体为疼痛模型,观察Mel对痛阈的影响。结果Mel30,60,120mg/kg剂量依赖性地增加小鼠痛阈,且于给药后1h达高峰,持续至2h仍有效。此外,无镇痛效应的Mel(10mg/kg)与哌替啶(10mg/kg)合用,能明显提高小鼠痛阈。结论Mel具有良好的镇痛作用,增大剂量完全能达到哌替啶的镇痛效应,且与哌替啶有明显协同效应。

Experimental study on the analgesic effects of Melatonin

Aim To study the analgesic effects of Mel atonin(Mel )and the synergistic analgesic effect of Mel with pethidine(Pt ).Methods Mel,given intraperitoneally(ip)at the dose of 30,60and 120mg /kg was e -valuated for its analgesic activity using the mouse hot-plate and acetic acid-induced writhing methods.Results Mel (30-120mg /kg)dose-dependently increased the pain thresholds in mic e .At 1hour after used,Mel exerts its maximal analgesic effect,and the an algesic effects of which lasted 2hou rs.Coadministration of Mel(10mg /kg)with Pt (10mg /kg)significantly in-creased antinociceptive responses in both hot-plate and acetic acid-in duced writhing tests.Conclusion Mel exerts a dose-related analgesic effect,which can arrive at the same analgesic level of Pt at the higher dose of Mel.Moreover,Mel also can synergy the an algesic response of Pt when given to-gether with Pt.