No-touch射频消融术治疗小肝癌的效果

目的:探究No-touch射频消融技术(No-touch radiofrequency ablation,No-touch-RFA)治疗小肝癌的效果。方法:选择2016年1月至2019年1月于许昌市中心医院就诊的小肝癌患者68例,按照手术方法的不同分为No-touch组(n=32)与传统射频组(n=36)。收集患者的一般资料、术前及术后生化指标谷丙转氨酶(alanine transaminase,ALT)、总胆红素(total bilirubin,TBIL)、血清白蛋白(albumin,Alb)、甲胎蛋白(alpha fetoprotein,AFP)],观察患者术后并发症发生情况,并随访2年,记录患者的总生存期、无瘤生存率及复发情况。结果:治疗后,两组患者的A FP均低于治疗前(P<0.05),两组间AFP比较,差异无统计学意义(P>0.05);治疗后,两组ALT、TBIL、Alb与治疗前的差异无统计学意义,且两组间的差异无统计学意义(P>0.05);No-touch组1年、2年总生存率分别为93.75%、87.50%,传统射频组1年、2年总生存率分别为80.56%、66.67%,差异有统计学意义(P<0.05);No-touch组1年、2年无瘤生存率为84.38%、71.88%;传统射频组1年、2年无瘤生存率分别为66.67%、47.22%,差异有统计学意义(P<0.05);No-touch组与传统射频组的1年复发率分别为15.63%、25.00%,差异无统计学意义(P>0.05);No-touch组与传统射频组的2年复发率分别37.50%、52.78%,差异有统计学意义(P<0.05);No-touch组的并发症发生率为3.13%,传统射频组为8.33%,差异无统计学意义(P>0.05)。结论:No-touch-RFA技术与传统射频消融技术均能降低AFP水平,而No-touch-RFA技术能提高患者的生存期。

Curative effects of No-touch radiofrequency ablation on small hepatocellular carcinoma

Objective:To explore the curative effects of No-touch radiofrequency ablation(No-touch-RFA)on small hepatocellular carcinoma(SHCC).Methods:A total of 68 patients with SHCC treated in the hospital were enrolled between January 2016 and January 2019.They were divided into a No-touch group(n=32)and a traditional radiofrequency group(n=36)according to different surgical methods.The general data of patients were collected,including preoperative and postoperative biochemical indexesalanine aminotransferase(ALT),total bilirubin(TBIL),serum albumin(Alb),alpha-fetoprotein(AFP)].The occurrence of postoperative complications was observed.And patients were followed up for 2 years to record overall survival,disease free survival(DFS)rate and recurrence.Results:After treatment,AFP in the 2 groups was decreased(P<0.05),but there was no significant difference between the 2 groups(P>0.05).There was no significant difference in ALT,TBIL and Alb before and after treatment in the two groups,and there was no significant difference between the 2 groups(P>0.05).The 1-year and 2-year overall survival rates in the No-touch group and the traditional radiofrequency group were 93.75%,87.50%and 80.56%,66.67%,and the differences were statistically significant(P<0.05).The 1-year and 2-year DFS rates in the No-touch group and the traditional radiofrequency group were 84.38%,71.88%and 66.67%,47.22%,and the differences were statistically significant(P<0.05).The 1-year recurrence rates in the No-touch group and the traditional radiofrequency group were 15.63%and 25.00%,but the difference was not statistically significant(P>0.05).The 2-year recurrence rates in the No-touch group and the traditional radiofrequency group were 37.50%and 52.78%,and the differences were statistically significant(P<0.05).The incidence rates of complications in the No-touch group and the traditional radiofrequency group were 3.13%and 8.33%,and the difference was not statistically significant(P>0.05).Conclusion:Both No-touch-RFA and traditional RFA can reduce AFP level.However,No-touch-RFA can prolong survival of patients.