151例天疱疮患者并发感染的回顾性研究

目的研究天疱疮并发感染、影响感染的因素以及感染对预后的影响,以提高天疱疮的治疗水平。方法对151例住院天疱疮患者的临床资料进行回顾性分析。结果 151例患者中57.6%发生感染,最常见的为皮肤金黄色葡萄球菌感染,其次为呼吸系统感染;感染的发生与糖尿病、低蛋白血症、疾病严重程度、疾病分型、治疗方案、糖皮质激素使用量以及住院时间相关,其中低蛋白血症还影响感染的严重程度;感染可影响天疱疮的预后,肺部感染为常见的死亡原因。结论积极有效的抗感染对天疱疮治疗非常重要,同时需纠正低蛋白血症,尽可能减少糖皮质激素用量,必要时联合静脉丙种球蛋白治疗。

Retrospective study on 151 cases of pemphigus complicated with infections

Objective To study the pemphigus complicated with infections, the risk factors of infection and the effects of infection on the prognosis, so as to improve the treatment of pemphigus. Methods The clinical data of 151 patients with pemphigus were analyzed retrospectively. Results In the total 151 patients, 57.6% were complicated with infections. The most common was skin infection by S.aureus, followed by the respiratory system infection. The related factors of infection concluded diabetes, hypoproteinemia, severity and classification of the disease, treatment, dose of steroid and hospitalization days, meanwhile hypoproteinemia also affected the severity of the infection. Infection affected the prognosis of pemphigus, and the main cause lead to death was pulmonary infection. Conclusion Providing positive and effective anti-infection treatment has an important role in the treatment of pemphigus. Sometimes it's also need to improve the hypoproteinemia, reduce the dose of steroid as far as possible and be combined with intravenous immunoglobulin therapy if necessary.