不同抗凝药物对妇科肿瘤术后深静脉血栓预防作用的临床对比研究

目的:探究不同抗凝药物对妇科肿瘤术后深静脉血栓预防效果。方法:选取自2013年2月至2015年4月间本院收治的妇科肿瘤进行手术的患者90例,按照随机分组对照原则将本组患者分成研究I组、研究II组和对照组,每组各有患者30例。对照组患者不予以抗凝药物治疗,研究I组的患者应用利伐沙班进行术后深静脉血栓的预防性治疗,而研究II组则采用低分子肝素进行治疗。然后对比观察三组患者的血清学指标、血流指标、下肢周径、凝血酶原时间以及术后并发症的发生情况。结果:结果显示,研究组中深静脉血栓发生率为13.33%,对照组为20.0%,比较差异具有显著性(P0.05),具有统计学意义。研究II组的血清学指标、血流指标、下肢周径、凝血酶原时间均较研究I组及对照组优,差异具有统计学意义(P0.05)。且研究组不良反应较对照组少,差异具有统计学意义(P0.05)。结论:研究表明,利伐沙班与低分子肝素均对术后深静脉血栓形成有预防作用,但比较而言,低分子肝素预防效果更佳,不良反应更少。

Clinical comparative study of different anticoagulant drugs in postoperative deep vein thrombosis prevention of gynecological tumors

Objectives:To explore the preventive effect of different anticoagulant drugs for deep vein thrombosis of gynecologic cancer.Methods:90 patients who received gynecological cancer surgery in our hospital from February 2013 to April 2015 were selected.In accordance with randomized controlled principle,they were divided into study group Ⅰ,study group Ⅱ and control group,with 30 patients in each group.Control group did not receive anticoagulant therapy,while patients in the study group Ⅰ received rivaroxaban postoperative deep vein thrombosis prophylaxis,and patients in study group Ⅱ received low molecular weight heparin for treatment.The serum markers,blood flow indicators,leg circumference,thrombin original time occurrence and postoperative complications of two groups were observed.Results:The results showed that the deep vein thrombosis incidence of study group was 13.33％,and it was 20.0％ in control group,with significant difference between two groups (P ＜0.05).Serum markers,blood flow indicators,leg circumference,thrombin original time occurrence and postoperative complications of study group Ⅱ were better than those in control group and study group Ⅰ,with significant difference (P ＜0.05).And adverse reactions in study group was less than that in control group,with significant difference (P ＜0.05).Conclusion:Rivaroxaban and low molecular weight heparin has a preventive effect on postoperative deep vein thrombosis,but low molecular weight heparin prophylaxis is more effective,with fewer adverse reactions.