178例急性自发性荨麻疹转归为慢性的危险因素回顾性分析

目的：分析影响急性自发性荨麻疹（ASU）转归为慢性自发性荨麻疹（CSU）的危险因素。方法：回顾性分析本院2018年11月至2019年10月178例ASU患者的人口学信息、发病季节、初发病程、自诉可疑过敏原、自体血清皮肤试验（ASST）、7日荨麻疹活动度评分（UAS7）、血常规、血清总IgE测定、治疗药物，Logistic回归分析ASU转归为CSU的危险因素。结果：178例ASU中42例（23.60%）转归为CSU,单因素分析自诉食物过敏（P<0.001）、 ASST试验阳性（P<0.001）、初发病程（P＜0.001）与ASU患者转归为CSU具有相关性；多因素Logistics回归分析示自诉食物过敏（P=0.029）、ASST试验阳性（P=0.043）、初发病程长（P＜0.001）均是影响ASU转归为CSU的独立危险因素。结论：食物过敏、ASST试验阳性、初发病程长是ASU患者转归为CSU的危险因素。

Retrospective analysis of risk factors for acute spontaneous urticaria developing into chronic spontaneous urticaria in 178 patients

Objective:To analyze the risk factors of acute spontaneous urticaria(ASU) developing into chronic spontaneous urticaria(CSU) in 178 patients. Methods:The data of 178 patients with ASU in Weifang People’s Hospital from November 2018 to October 2019 was analyzed, including age, sex, first onset season and duration, self-report of suspected allergens, autologous serum skin test(ASST), urticaria activity score 7(UAS7), blood routine test, serum total IgE level and therapeutic drugs. Results:Of 178 patients with ASU, 42(23.60%) developed into CSU. The univariate analysis showed food allergy(P<0.001), positivity for ASST(P<0.001) and long first onset duration(P<0.001) were associated with ASU developing into CSU. Logistic regression analysis showed that food allergy(P=0.029), positivity ASST result(P<0.043) and long first onset duration(P<0.001) were risk factors for ASU developing into CSU. Conclusion:Food allergy, positivity for ASST and long first onset duration are the risk factors for ASU developing into CSU.