白细胞介素17与慢性荨麻疹相关性的Meta分析

目的：系统评价白细胞介素17（Interleukin-17, IL-17）与慢性荨麻疹的相关性。方法：检索中国知网、万方数字化期刊全文数据库、VIP中国科技期刊全文数据库、中国生物医学文献数据库、PubMed、Cochrane Library、Web of Science等数据库，搜集有关IL-17与慢性荨麻疹相关的病例对照研究。时间范围为各数据库建库至2019年12月31日。由2名独立评价者进行文献筛选、资料提取和纳入研究偏倚风险评价，后采用Cochrance协作网提供的RevMan5.3软件进行Meta分析。结果：共纳入11个研究，其中慢性荨麻疹患者617例，对照组522例。Meta分析结果显示，慢性荨麻疹组患者血清中IL-17浓度明显升高，与对照组相比，差异具有统计学意义［SMD=1.52, 95%CI(1.13,1.91), Z=7.64, P<0.00001］。结论：慢性荨麻疹患者血清中IL-17明显升高，IL-17可能与慢性荨麻疹具有相关性。

Association between interleukin-17 and chronic urticaria:a meta-analysis

Objective:To systematically evaluate the association between Interleukin-17(IL-17)and chronic urticaria.Methods:The case-control studies on IL-17 and chronic urticaria were searched in CNKI,Wanfang Database,CQVIP,Sinomed Database,PubMed,Cochrane Library,Web of Science from inception to December 31,2019.Two reviewers screened literature,extracted data,and assessed risk bias of included researches.Meta-analysis was performed by RevMan 5.3 software.Results:A total of 11 studies were included,including 617 patients with chronic urticaria and 522 controls.The results of meta-analysis showed that IL-17 level in the chronic urticaria group was significantly higher than that in the control group,with a significant differenceSMD=1.52,95%CI(1.13,1.91),Z=7.64,P<0.00001].Conclusion:The level of IL-17 is elevated in the patients with chronic urticaria,and IL-17 may be associated with chronic urticaria.