银屑病发病易感基因与表观遗传调控研究进展

银屑病是一种常见的慢性炎症性皮肤病,它是一种复杂的多因素性疾病,确切发病机制尚不明确,位于主要组织相容性复合体区域染色体6p21.3上的主要效应基因所起的遗传效应只占银屑病遗传可能性的三分之一,因此这不能完全解释银屑病的发病机制。研究发现,表观遗传学机制也参与银屑病的发病,如DNA甲基化、乙酰化修饰和MicroRNA调节。本文对银屑病发病易感基因及表观遗传调控进展进行综述。

Update of susceptibility genes and epigenetic regulation of psoriasis

Psoriasis is a common chronic inflammatory skin disease. It is a complex multifactorial disease and the pathogenesis is not fully understood. The dominant effect genes are located on chromosome 6p21.3 within the major histocompatibility complex region accounting for one-third of genetic contribution and therefore that cannot fully explain the disease pathogenesis. Studies reported that epigenetic mechanisms are also involved in the pathogenesis of psoriasis, such as DNA methylation, acetylation modification and MicroRNA regulation. The update of susceptibility genes and epigenetic regulation of psoriasis were reviewed in this paper.