无抽搐电休克与氯丙咪嗪联合治疗强迫症的对照研究

目的比较无抽搐电休克与氯丙咪嗪联合治疗强迫症的疗效及安全性。方法将74例强迫症患者随机分为观察组和对照组，每组37例。观察组采用无抽搐电休克联合氯丙咪嗪治疗，对照组单纯以氯丙咪嗪治疗，疗程4周，采用Y—BOCS及TESS评定疗效及安全性。结果在治疗后第2周、第4周末时，观察组Y--BOCS评分显著低于对照组（P〈0.01）。两组不良反应比较差异无显著性（P〉0．05）。结论无抽搐电休克与氯丙咪嗪联合治疗强迫症的疗效优于单用氯丙咪嗪。

A Control Study of Modified Electric Convulsive Therapy Combined with Clomipramine in the Treatnent of Obsessive-Compulsive Disorder

Objective To evaluate the efficacy and safety of Modified electric convulsive therapy (MECT) combined with clomipramine in the treatment of obsessive-compulsive disorder (OCD). Methods Fourth-seven patients with OCD were randomly divided into two groups. The patients (n=37, study group) were treated with MECT combined with clomipramine and the patients (n=37 in control group) were treated with clomipramine alone. The efficacy and safety were assessed with Y-BOOS and TESSscales. Results The scores of Y-BOOS scale in observed group were significantly lower than that in control group at the end of 2 weeks and 4 weeks after the treatment (P<0.01). There was no significant difference in side effects between the two groups (P>0.05). Conclusion MECT combined with clomiprarmine was more effective than clomipramine mono-therapy in the treatment of OCD.