帕罗西汀与氟西汀对脑卒中后抑郁总体康复影响的对照研究

目的：比较帕罗西汀与氟西汀（百忧解）对脑卒中后抑郁总体康复的影响。方法：将符合入组标准的脑卒中后抑郁患者随机分为帕罗西汀组，氟西汀组，用汉密顿抑郁量表（HAMD），汉密顿焦虑量表（HAMD），副反应量表（TESS）和改良爱丁堡与斯堪的维亚评分（SSS）进行评估。结果：帕罗西汀组与氟西汀组治疗前与治疗后第4，8周SSS评分均有显著差异，帕罗西汀组与氟西汀组之间无差异。治疗后第2周帕罗西汀组与氟西汀组HAMA评分有显著差异。结论：帕罗西汀与氟西汀均能有效地治疗脑卒中后抑郁，加快病人总体康复，帕罗西汀具有较好的治疗依从性。

A controlled trial comparing the total rehabilitation of paroxetine and fluoxtine in the treatment of poststroke depression

Objective To study the efficacy of the total rehabilitation of paroxetine and fluoxtine in the treatment of poststroke depression.Method Patients with diagnosis of poststroke depression and fulfilling the admission criteria to the study were randomly assigned to two groups that were treated with paroxetine and fluoxtine.The therapeutic response were evaluated with HAMD,HAMA,TESS and SSS.Results There were significant difference with SSS between before and post the treatment of both paroxetine and fluoxtine.The effect of paroxetine were superior to that of fluoxtine with significant difference as measured with the HAMA in the 2nd week.Conclusion Both paroxetine and fluoxtine accelerated the total rehabilitation of poststroke depression.Paroxetine can ameliorate anxiety more efficiently and the treatment obedience were superior to that of fluoxtine.