食物不耐受在慢性荨麻疹病因诊断中的临床意义

探讨慢性荨麻疹与食物不耐受的相关性,为其病因诊断及防治提供参考依据。采用美国B IOMER ICA公司生产的食物不耐受体外检测试剂盒（ELISA方法）检测慢性荨麻疹患者血清中14种食物特异性IgG抗体,并对结果进行统计分析。结果表明,74例患者中,食物特异性IgG总阳性率为63.5%（47/74）。IgG阳性率在10%以上的食物有六种,阳性率由高至低分别为鸡蛋（24.3%）、牛奶（24.3%）,螃蟹（18.9%）、大豆（18.3%）、小麦（17.6%）、虾（13.5%）。IgG浓度分级结果表明,仅对1种食物不耐受者居多,占全部IgG阳性病例的46.8%（22/47）;男、女患者食物特异性IgG阳性率以及各种食物的IgG阳性率在不同性别间均无显著性差异（P〉0.05）。结论：慢性荨麻疹与食物不耐受密切相关,鸡蛋、牛奶、螃蟹、大豆、小麦、虾是本地区慢性荨麻疹患者食物不耐受最常见的主要致敏源,食物不耐受检测对慢性荨麻疹患者的病因诊断和防治具有重要意义。

Clinical Significance of Food Specific IgG Detection in Patients with Chronic Urticaria

To investigate the relationship between food intolerance and chronic urticaria,a total of 74 patients with chronic urticaria were enrolled in this study.Fourteen food-specific IgG antibodies in serum were detected by ELISA assay.The results showed that the total food specific IgG positive rates in patients was 63.5%,and six kinds of food with the highest food specific IgG positive were egg(24.3%),milk(24.3%),crab(18.9%),soybean n(18.3%),wheat(17.6%),and shrimp(13.5%) respectively.The positive rates were not significant different between male and female(P>0.05).The results indicate that egg,milk,crab,soybean,wheat and shrimp were the main six types of food allergens in patients with chronic urticaria in this area.Detection of serum food-specific IgG in patients with chronic urticaria have great importance in the therapy and prevention of chronic urticaria.