微小 RNA 对巨噬细胞发育和功能调节的研究进展

微小RNA(miRNAs)是一类长度18 ~25 nt 的单链非编码蛋白RNA,在调节免疫细胞的成熟、发育、增殖、分化和活化,以及抗体产生、免疫反应、炎症介质释放等方面起重要作用。巨噬细胞是先天性免疫系统中的一个成员,同时参与适应性免疫应答的启动和效应过程。MiRNAs 在巨噬细胞发育、活化、分化以及衰老等生物学过程中的调节作用受到了极大关注。本文将从miRNAs 对巨噬细胞发育、极化、功能及凋亡的调节和与巨噬细胞相关疾病等方面进行综述,以期为miRNAs与巨噬细胞的相关研究提供理论参考。

Research progress of microRNAs on development and function regulation of macrophages

MicroRNAs (miRNAs) are a kind of non-coding single stranded RNAs molecules formed with length of 18-25 nt,which play an important role in the maturation,development,proliferation,differentiation and activation of immune cells,as well as antibody production,immune response and release of inflammatory mediators.Macrophages are members of the innate immune system and also involved in the initiation and effector processes of adaptive immune responses.MiRNAs have drawn a lot of attention to the biological processes in development,activation,differentiation and senescence of macrophage.In this paper,the influences of miRNAs in development,polarization,function and apoptosis of macrophages,and macrophage-related diseases were reviewed in order to provide theoretical references for the related research of miRNAs and macrophages.