| miR-7与胃癌的研究进展 |
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| 引用本文： | 邓玲,朱欢.miR-7与胃癌的研究进展[J].国际病理科学与临床杂志,2016(3):322-326. |
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| 作者姓名： | 邓玲 朱欢 |
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| 作者单位： | 1. 南华大学附属第一医院肿瘤科，湖南省胃癌研究中心，衡阳 湖南 421001;2. 南华大学附属第一医院肿瘤科，湖南省胃癌研究中心，衡阳 湖南 421001; 南华大学肿瘤研究所，衡阳 湖南 421001 |
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| 基金项目： | 国家自然科学基金(81374013)；湖南省卫计委科研课题(A2015-2)。@@@@This work was supported by The National Natural Scientiifc Foundation of China(81374013)，hTe Scientiifc Research Foundation of Health and Family Planning Committee of Hunan Province(A2015-2)，P. R. China |
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| 摘 要： | 近年来microRNA(miRNA)领域已成为研究热点。miR-7是其中重要的成员，在多种肿瘤细胞中表达下调，充当抑癌基因的角色。目前研究发现，miR-7在胃癌中存在多种信号通路调控不同的靶基因抑制胃癌的发生与发展。miR-7可能成为胃癌诊断、治疗和预后的标志物及潜在生物治疗靶分子。本文就miR-7与胃癌的发生发展、相关靶基因和治疗方面的研究进展作一综述。
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| 关 键 词： | 胃癌 进展 靶基因 治疗 |
Research progress of miR-7 in gastric cancer |
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| Abstract: | In recent years, microRNA (miRNA) has become a hot topic. miR-7 is one of the important members of miRNA. It downregulates in a variety of tumor cells, acts as suppressor genes. Some current studies has reported that miR-7 can regulate target genes though many different signaling pathways, thus to inhibit the occurrence and development of gastric cancer. miR-7 is likely to be the biological markers of diagnosis, treatment and prognosis, and potential therapeutic target in gastric cancer. hTe relationship of miR-7 and the development of gastric cancer, relevant target genes and progress of treatment are reviewed in this paper. |
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| Keywords: | gastric cancer development target gene therapy |
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