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| 山东省潍坊东部地区精神分裂症1号染色体基因扫描研究 | |
| 引用本文： | 陈刚,温晓燕,朱海宁,魏然,周鹏,栾萌,高春义,朱建平,翁正.山东省潍坊东部地区精神分裂症1号染色体基因扫描研究[J].中华医学遗传学杂志,2007,24(3):288-292. |
| 作者姓名： | 陈刚 温晓燕 朱海宁 魏然 周鹏 栾萌 高春义 朱建平 翁正 |
| 作者单位： | 1. 250062,济南,山东省医学科学院基础医学研究所医学遗传学与基因工程重点实验室,山东省现代医用药物与技术重点实验室 2. 山东省潍坊市精神卫生中心 3. 山东省精神卫生中心 |
| 基金项目： | 国家863项目（2002AA223021）;国家自然科学基金（30440042）;山东省自然科学基金重点项目（Z2004C10） |
| 摘 要： | 目的对精神分裂症患者及正常对照者的1号染色体进行扫描,查找精神分裂症的关联位点。方法在1号染色体上间隔10cM（厘摩）遗传距离,选择了31个微卫星遗传位点,用DNA混合池的方法对119例精神分裂症患者与119名正常对照者的DNA样本分别混合后进行基因组扫描。经卡方检验分析,对比患者组与对照组的等位基因峰型比率的差异。结果在D1S2878遗传位点患者组与对照组的等位基因频率差异有统计学意义,P〈0.01。结论山东省潍坊东部地区精神分裂症患者群体中存在与1号染色体的关联区域。 |
| 关 键 词： | 精神分裂症 染色体 遗传 基因组 基因池 |
| 修稿时间： | 2006-08-11 |
Association mapping of schizophrenia loci on chromosome 1 by use of pooled DNA genomic screening in eastern Shandong peninsula |
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| CHEN Gang,WEN Xiao-yan,ZHU Hai-ning,WEI Ran,ZHOU Peng,LUAN Meng,GAO Chun-yi,ZHU Jian-ping,WENG Zheng.Association mapping of schizophrenia loci on chromosome 1 by use of pooled DNA genomic screening in eastern Shandong peninsula[J].Chinese Journal of Medical Genetics,2007,24(3):288-292. | |
| Authors: | CHEN Gang WEN Xiao-yan ZHU Hai-ning WEI Ran ZHOU Peng LUAN Meng GAO Chun-yi ZHU Jian-ping WENG Zheng |
| Affiliation: | 1.Laboratory of Medical Genetics, Institute of Basic Medicine, Shandong Academy of Medical Sciences, Jinan, Shandong , 250062 P. R. China; 2. Key laboratory for Modern Medicine and Technology of Shandong Province, Jinan , Shandong , 250062 P. R . China ; 3. Weifang Mental Health Center, Wefang , Shandong , 262400 P . R . China ; 4.Shandong Mental Health Center, Jinan, Shandong, 250014 P. R. China |
| Abstract: | Objective To find out association mapping of loci related to schizophrenia on chromosome 1 with microsatellite markers in DNA pooling samples from schizophrenic cases and normal controls in Shandong peninsula. Methods A total of 31 microsatellite markers on chromosome 1 spaced at approximately 10 cM were scanned to two separated DNA pooling samples consisting of 119 schizophrenic cases and 119 normal controls respectively. Statistic analysis was performed by Chi-square test method to compare the difference between the ratio of each allele between the two pooling samples. Results Significant statistic difference was found at D1S2878 between cases and controls, and the P value was <0.01 at this loci. Conclusion D1S2878 locus on chromosome 1 associates with schizophrenia in Shandong peninsula. Fine mapping and searching for candidate genes are warranted in this region. |
| Keywords: | schizophrenia chromosomes heredity genorne gene pool |
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