女性小儿单纯肥胖症患者血清leptin及其相关因子含量的相关性

目的：探讨了女性小儿单纯性肥胖症患儿血清瘦素（leptin）、神经肽Y（NPY）和脂联素（ADP）的含量变化及相关性。方法：应用放射免疫分析对32例女性小儿单纯肥胖症患者进行了血清leptin、NPY和ADP水平检测，并与35名正常女性小儿作比较。结果：女性小儿单纯性肥胖症患者血清leptin、NPY水平非常显著地高于正常女童组（P〈0．01），而ADP水平则非常显著地低于正常女童组（P〈0．01），且血清leptin水平与NPY水平呈明显的正相关（r=0．6014，P〈0．01），与ADP水平呈明显的负相关（r=-0．4786，P〈0．01）。结论：检测女性小儿单纯性肥胖症患儿血清leptin、NPY和ADP水平的变化对了解病情、指导临床实践均具有一定的临床实用价值。

Correlations of Serum Levels of Leptin and Other Related Factor (NPY, ADP) in Female Children with Simple Obesity

Objective To study the changes of serum levels of leptin, NPY and ADP in female children with simple obesity. Methods Serum levels of leptin, NPY and ADP were measured with radioimmunoassay (RIA) in 32 female children with simple obesity and 35 controls. Results The serum levels of leptin, NPY were significantly higher in the obese children than those in controls (P<0.01), while the serum levels of ADP were significantly lower (P<0.01). Serum leptin levels were significantly positively correlated (r=0.6014, P<0.01) with NPY levels but were negatively correlated (r=-0.4786, P<0.01) with adiponectin (ADP) levels. Conclusion Determination of serum leptin, NPY and ADP levels is of help for judgement of degree of obesity as well as outcome prediction in female children.