卵巢不典型子宫内膜异位症的恶变潜能研究

目的：探讨卵巢不典型子宫内膜异位症的恶变潜能。方法：观察12例合并子宫内膜异位症的子宫内膜样卵巢癌手术标本的形态学特点,并对各例癌组织和癌变子宫内膜异位症组织分别采用微卫星标记检测10q23.3部位的杂合子缺失,结果：12例癌旁子宫内膜异位症的形态学观察结果显示,8例合并嗜酸性上皮化生,5例同时有明显的细胞异型性,符合不典型子宫内膜异位症,并可见与周围癌组织有移行现象,从不典型子宫内膜异位症的病普组织中,有2例检测出与周围癌组织相同位点的基因改变。结论：卵巢的不典型子宫内膜异位症可能是具有恶变潜能的癌前,病变。

The malignant potential of ovarian atypical endometriosis

Objective To investigate the malignant potential of ovarian atypical endometriosis and ovarian endometrioid adenocarcinoma. Methods 12 cases of ovarian endometroid adenocacinoma with associated endometriosis were reviewed retrospectively. Microsatellite markers were used to detect the loss of heterozygosity on chromosome 10q23 in ovarian carcinoma and their coexisting endometriosis. Results Among the 12 cases, benign eosinophilic metaplasia was observed in 8 cases, 5 of which (41.7%) with atypia. In these 5 cases, a spectrum of benign-atypical endometriosis with a transition to endometrioid adenocarcinoma was identified, and common genetic lesions were also detected in 2 of the 5 atypical endometriosis and their coexisting carcinomas. Conclusion Histological observations as well as the molecular genetic evidence indicate that ovarian atypical endometriosis may possess a precancerous potential or play a role in the pathogenesis of certain malignant ovarian cancers.