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| 缺血后适应对大鼠局灶性脑缺血再灌注后谷氨酸的影响 | |
| 引用本文： | 鲁文果,姜丹,孙仁虎,张苏明.缺血后适应对大鼠局灶性脑缺血再灌注后谷氨酸的影响[J].神经解剖学杂志,2011,27(6):628-632. |
| 作者姓名： | 鲁文果 姜丹 孙仁虎 张苏明 |
| 作者单位： | 1. 武汉科技大学附属天佑医院神经内科,武汉,430064 2. 华中科技大学附属协和医院普外科,武汉,430022 3. 华中科技大学附属同济医院神经内科,武汉,430030 |
| 基金项目： | 武汉市科技计划项目(20066009138-09) |
| 摘 要： | 目的:研究缺血后适应对大鼠局灶性脑缺血再灌注后谷氨酸(Glu)浓度变化的影响。方法:建立大鼠大脑中动脉阻塞(middle cerebral artery occlusion,MCAO)模型,将36只雄性SD大鼠随机分为假手术(Sham)组、脑缺血再灌注(I/R)组和缺血后适应(I Postcond)组,每组12只。应用高效液相色谱检测缺血脑组织匀浆Glu浓度。结果:局灶脑缺血再灌注6 h后,I Postcond组Glu浓度相较I/R组明显降低(P<0.01),局灶脑缺血再灌注24 h后,I Postcond组Glu浓度较I/R组低,但两者差异亦无显著性(P>0.05)。结论:本研究表明,I Postcond能够减轻MCAO大鼠模型中I/R损伤。细胞间隙Glu清除的加速可能是其重要保护机制之一。 |
| 关 键 词： | 缺血后适应 缺血再灌注 谷氨酸 大脑中动脉阻塞 大鼠 |
Effect of ischemic postconditioning on glutamate levels after focal cerebral ischemia reperfusion in rat |
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| Lu Wenguo , Jiang Dan , Sun Renhu , Zhang Suming.Effect of ischemic postconditioning on glutamate levels after focal cerebral ischemia reperfusion in rat[J].Chinese Journal of Neuroanatomy,2011,27(6):628-632. | |
| Authors: | Lu Wenguo Jiang Dan Sun Renhu Zhang Suming |
| Affiliation: | Lu Wenguo1,Jiang Dan1,Sun Renhu2,Zhang Suming3 (1.Department of Neurology of Tianyou Hospital of Wuhan University of Science and Technology,Wuhan 430064,2.Department of General Surgery of Union Hospital of Huazhong University of Science and Technology,Wuhan 430022,3.Department of Neurology of Tongji Hospital of Huazhong University of Science and Technology,Wuhan 430030,China) |
| Abstract: | Objective: To investigate the effect of ischemic postconditioning on glutamate after focal cerebral ischemia reperfusion.Methods: The MCAO(middle cerebral artery occlusion) models of rats were made.36 male Sprague-Dawley rats were randomly divided into 3 groups(n=12): Sham-operate(Sham) group,ischemia/reperfusion(I/R) group and ischemic postconditioning(I Postcond) group.We used high performance liquid chromatography(HPLC) to examine the glutamate concentration of the ischemic brain tissue homogenate.Result... |
| Keywords: | ischemic postconditioning ischemia/reperfusion glutamate middle cerebral artery occlusion rat |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |
