| mTOR_P70S6K信号通路在小儿脑胶质瘤中的表达及其临床意义 |
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| 引用本文： | 陈鹏,宋涛.mTOR_P70S6K信号通路在小儿脑胶质瘤中的表达及其临床意义[J].细胞与分子免疫学杂志,2011,27(4):442-443,445. |
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| 作者姓名： | 陈鹏 宋涛 |
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| 作者单位： | 1. 湖南省儿童医院,湖南,长沙,410007
2. 中南大学湘雅医院,湖南长沙,410078 |
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| 基金项目： | 湖南省卫生厅科研课题指导项目(B2006-176) |
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| 摘 要： | 目的:探讨mTOR_P70S6K信号通路在小儿脑胶质瘤组织中的表达及其临床意义。方法:随机选取脑胶质瘤患儿88例,采用SP免疫组化方法,检测脑胶质瘤组织和正常脑组织中mTOR蛋白及P70S6K蛋白的表达。并分析其与脑胶质瘤组织临床分级之间的关系。结果:mTOR蛋白及P70S6K蛋白在脑胶质瘤组织中的阳性表达率分别为81.58%(31/38)和78.95%(30/38),明显高于其在正常脑组织中的阳性表达率分别为15%(3/20)和10%(2/20)](P<0.01)。mTOR蛋白和P70S6K蛋白在脑胶质瘤组织中的表达呈正相关(r=0.68,P<0.05),且两者在正常脑组织中的表达亦正相关性(r=0.89,P<0.01)mTOR蛋白及P70S6K蛋白阳性表达率在脑胶质瘤高级别组(Ⅲ~Ⅳ级)中的表达均明显高于低级别组(Ⅰ~Ⅱ级),说明随着肿瘤级别的升高二者的表达也增强。结论:mTOR_P70S6K信号通路在小儿脑胶质瘤中发生了特异性的激活。该通路可能与小儿脑胶质瘤的发生、发展密切相关。
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| 关 键 词： | 脑胶质瘤 临床病理学 mTOR_P70S6K信号通路 |
Expression and clinical significance of mTOR/P70S6K signaling pathway in children glioma |
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| CHEN Peng,SONG Tao.Expression and clinical significance of mTOR/P70S6K signaling pathway in children glioma[J].Journal of Cellular and Molecular Immunology,2011,27(4):442-443,445. |
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| Authors: | CHEN Peng SONG Tao |
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| Affiliation: | CHEN Peng1,SONG Tao2 1Hunan Children's Hospital,Changsha 410007,2Xiangya Hospital of Central South University,Changsha 410078,China |
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| Abstract: | AIM:To investigate the expression of mTOR/P70S6K signaling pathway in glioma,and evaluate its clinical significance in clinicopathological status of children with glioma.METHODS: 88 children with glioma were examined for mTOR protein and P70S6K protein expression by SP immunohistochemistry,respectively.RESULTS: The positive expression rates of mTOR protein and P70S6K protein in glioma tissues were 81.58%(31/38) and 78.95%(30/38),respectively,which were both significantly higher than those in normal brain ti... |
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| Keywords: | glioma clinical pathology mTOR/P70S6K signaling pathway |
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