| 非编码RNA在脑缺血再灌注损伤中的作用 |
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| 引用本文： | 张毅,冯康倪,陈鉴涛,梁孟亚.非编码RNA在脑缺血再灌注损伤中的作用[J].中国病理生理杂志,2021(2):347-355. |
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| 作者姓名： | 张毅 冯康倪 陈鉴涛 梁孟亚 |
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| 作者单位： | 中山大学附属第一医院心脏外科 |
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| 基金项目： | 广东省自然科学基金面上项目(No.2019A1515010218)。 |
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| 摘 要： | 脑卒中(stroke)是导致成年人残疾和死亡的第二大病因,缺血性脑卒中约占所有脑卒中病例的87%1],成为了现代社会健康和生活质量的主要威胁。缺血性脑卒中(ischemic stroke)由于脑血流量严重减少,脑组织缺乏血液和氧气供应,最终导致神经元细胞死亡和脑梗死2]。
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| 关 键 词： | 脑缺血再灌注损伤 长链非编码RNA 微小RNA 细胞凋亡 自噬 |
Role of noncoding RNA in cerebral ischemia-reperfusion injury |
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| ZHANG Yi,FENG Kang-ni,CHEN Jian-tao,LIANG Meng-ya.Role of noncoding RNA in cerebral ischemia-reperfusion injury[J].Chinese Journal of Pathophysiology,2021(2):347-355. |
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| Authors: | ZHANG Yi FENG Kang-ni CHEN Jian-tao LIANG Meng-ya |
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| Affiliation: | (The Second Department of Cardiac Surgery,The First Affiliated Hospital of Sun Yat-sen University,Guangzhou 510080,China) |
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| Abstract: | Cerebral ischemia-reperfusion injury(CIRI)refers to the phenomenon that the recovery of blood flow leads to the destruction of brain structure and the aggravation of metabolic damage of nerve function after cerebral ischemia.The pathophysiological mechanism of CIRI is complicated,which mainly involves biological processes such as apoptosis,inflammation,oxidative stress,autophagy and so on.Studies have shown that long noncoding RNAs(lncRNAs)and microRNAs(miRNAs)play an important role in the occurrence and development of many diseases.However,the mechanism of noncoding RNAs in CIRI has not been fully clarified.This article reviews the roles of lncRNAs and miRNAs in CIRI in order to provide a direction for further exploration in the future. |
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| Keywords: | Cerebral ischemia-reperfusion injury Long noncoding RNA MicroRNA Apoptosis Autophagy |
| 本文献已被 CNKI 维普 等数据库收录！ |
