| 蛋白激酶B的研究进展 |
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| 引用本文： | 王华祖,龚兴国.蛋白激酶B的研究进展[J].中国病理生理杂志,2003,19(11):1521-1526. |
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| 作者姓名： | 王华祖 龚兴国 |
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| 作者单位： | 浙江大学生命科学院, 浙江杭州310027 |
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| 基金项目： | 浙江省自然科学基金资助项目 (No .396 0 0 7)，浙江大学曹光彪高科技基金资助项目 (No .1710 2 6 ) |
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| 摘 要： | Protein kinase B (Akt) is a Ser/Thr kinase, which in mammals comprise three highly ho-mologous members known as PKBα/Aktl, PKBβ/Akt2 and PKBγ/Akt3. PKB is activated by hormones,growth factor and extra cellular matrix. The activation occurs downstream of PI3K. PKB phosphorylates and regulates the function of many cellular protein involved in processes that include survival, apoptosis, proliferation,glycogen metabolism and cancer progression. Although many mechanisms remains to be fully characterized, the research of PKB is thought to have a useful profect.
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| 关 键 词： | 蛋白激酶B 细胞存活 糖代谢 |
| 文章编号： | 1000-4718(2003)11-1521-06 |
| 收稿时间： | 2002-06-18 |
Progress in protein kinase B |
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| WANG Hua-zu,GONG Xing-guo.Progress in protein kinase B[J].Chinese Journal of Pathophysiology,2003,19(11):1521-1526. |
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| Authors: | WANG Hua-zu GONG Xing-guo |
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| Affiliation: | Life Science College, Zhejiang University, Hangzhou 310027, China |
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| Abstract: | Protein kinase B (Akt) is a Ser/Thr kinase, which in mammals comprise three highly homologous members known as PKBα/Akt1, PKBβ/Akt2 and PKBγ/Akt3. PKB is activated by hormones?growth factor and extra cellular matrix. The activation occurs downstream of PI3K. PKB phosphorylates and regulates the function of many cellular protein involved in processes that include survival, apoptosis, proliferation, glycogen metabolism and cancer progression. Although many mechanisms remains to be fully characterized, the research of PKB is thought to have a useful profect. |
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| Keywords: | Protein kinase B Cell survival Glycogen metabolism |
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