| DAB2IP 基因的研究进展 |
| |
| 引用本文： | 袁妍,陈海滨.DAB2IP 基因的研究进展[J].中国病理生理杂志,2011,27(7):1445-1449. |
| |
| 作者姓名： | 袁妍 陈海滨 |
| |
| 作者单位： | Department of Histology and Embryology, Shantou University Medical College, Shantou 515041, China |
| |
| 基金项目： | 国家自然科学基金资助项目 |
| |
| 摘 要： | Human DAB2 interaction protein (DAB2IP) is a novel member of Ras GTPase-activating protein family. It interacts directly with disabled-2 protein (DAB2/DOC2) which suppresses growth of cancers derived from different tissues, including mammary, prostate and ovarian cancers. DAB2IP was identified as an immediate downstream effector mediated by DAB2/DOC2. DAB2IP and DAB2/DOC2 form a unique protein complex that has a negative regulatory effect on the Ras-mediated signal pathway. It is demonstrated that DAB2IP is a tumor suppressor gene inactivated by methylation in several cancers. This article reviews the structure and biological functions of DAB2IP gene as well as its potential roles in carcinogenesis and evolution.
|
| 关 键 词： | 基因 DAB2IP 基因 DAB2 基因调节 甲基化 |
| 收稿时间： | 2010-12-05 |
Progress on DAB2IP gene |
| |
| YUAN Yan,CHEN Hai-bin.Progress on DAB2IP gene[J].Chinese Journal of Pathophysiology,2011,27(7):1445-1449. |
| |
| Authors: | YUAN Yan CHEN Hai-bin |
| |
| Affiliation: | Department of Histology and Embryology, Shantou University Medical College, Shantou 515041, China |
| |
| Abstract: | Human DAB2 interaction protein (DAB2IP) is a novel member of Ras GTPase-activating protein family. It interacts directly with disabled-2 protein (DAB2/DOC2) which suppresses growth of cancers derived from different tissues, including mammary, prostate and ovarian cancers. DAB2IP was identified as an immediate downstream effector mediated by DAB2/DOC2. DAB2IP and DAB2/DOC2 form a unique protein complex that has a negative regulatory effect on the Ras-mediated signal pathway. It is demonstrated that DAB2IP is a tumor suppressor gene inactivated by methylation in several cancers. This article reviews the structure and biological functions of DAB2IP gene as well as its potential roles in carcinogenesis and evolution. |
| |
| Keywords: | Genes DAB2IP Genes DAB2 Gene regulation Methylation |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
| 点击此处可从《中国病理生理杂志》浏览原始摘要信息 |
|
点击此处可从《中国病理生理杂志》下载全文 |
